{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:50:35Z","timestamp":1775523035425,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The use of allosteric modulators as preferred therapeutic agents against classic orthosteric ligands has colossal advantages, including higher specificity, fewer side effects and lower toxicity. Therefore, the computational prediction of allosteric sites in proteins is receiving increased attention in the field of drug discovery. Allosite is a newly developed automatic tool for the prediction of allosteric sites in proteins of interest and is now available through a web server.<\/jats:p>\n               <jats:p>Availability: The Allosite server and tutorials are freely available at http:\/\/mdl.shsmu.edu.cn\/AST<\/jats:p>\n               <jats:p>Contact: \u00a0jian.zhang@sjtu.edu.cn<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt399","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:34:28Z","timestamp":1373502868000},"page":"2357-2359","source":"Crossref","is-referenced-by-count":198,"title":["Allosite: a method for predicting allosteric sites"],"prefix":"10.1093","volume":"29","author":[{"given":"Wenkang","family":"Huang","sequence":"first","affiliation":[{"name":"1 Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China and 2Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu 215123, China"}]},{"given":"Shaoyong","family":"Lu","sequence":"additional","affiliation":[{"name":"1 Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China and 2Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu 215123, China"}]},{"given":"Zhimin","family":"Huang","sequence":"additional","affiliation":[{"name":"1 Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China and 2Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu 215123, China"}]},{"given":"Xinyi","family":"Liu","sequence":"additional","affiliation":[{"name":"1 Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China and 2Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu 215123, China"}]},{"given":"Linkai","family":"Mou","sequence":"additional","affiliation":[{"name":"1 Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China and 2Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu 215123, China"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[{"name":"1 Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China and 2Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu 215123, China"}]},{"given":"Yanlong","family":"Zhao","sequence":"additional","affiliation":[{"name":"1 Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China and 2Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu 215123, China"}]},{"given":"Yaqin","family":"Liu","sequence":"additional","affiliation":[{"name":"1 Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China and 2Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu 215123, China"}]},{"given":"Zhongjie","family":"Chen","sequence":"additional","affiliation":[{"name":"1 Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China and 2Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu 215123, China"}]},{"given":"Tingjun","family":"Hou","sequence":"additional","affiliation":[{"name":"1 Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China and 2Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu 215123, China"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"1 Department of Pathophysiology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China and 2Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu 215123, China"}]}],"member":"286","published-online":{"date-parts":[[2013,7,9]]},"reference":[{"key":"2023070311400298600_btt399-B8","volume-title":"Introduction to Statistical Pattern Recognition","author":"Fukunaga","year":"1990"},{"key":"2023070311400298600_btt399-B1","doi-asserted-by":"crossref","first-page":"D663","DOI":"10.1093\/nar\/gkq1022","article-title":"ASD: a comprehensive database of allosteric proteins and modulators","volume":"39","author":"Huang","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2023070311400298600_btt399-B2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jmgm.2012.12.011","article-title":"Toward an understanding of the sequence and structural basis of allosteric proteins","volume":"40","author":"Li","year":"2013","journal-title":"J. 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