{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T01:30:05Z","timestamp":1778117405628,"version":"3.51.4"},"reference-count":4,"publisher":"Oxford University Press (OUP)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Non-linear calibration is a widely used method for quantifying biomarkers wherein concentration-response curves estimated using samples of known concentrations are used to predict the biomarker concentrations in the samples of interest. The R package nCal fills an important gap in the open source, stand-alone software for performing non-linear calibration. For curve fitting, nCal provides a new implementation of a robust, Bayesian hierarchical five-parameter logistic model. nCal supports a simple graphical user interface that can be used by laboratory scientists, and contains functionality for importing data from the multiplex bead array assay instrumentation.<\/jats:p>\n               <jats:p>Availability: The R package \u2018nCal\u2019 is available from http:\/\/cran.r-project.org\/web\/packages\/nCal\/ under GPL-2 or later.<\/jats:p>\n               <jats:p>Contact: \u00a0yfong@fhcrc.org<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary information is available in the form of an R package vignette at the above repository and an FAQ at http:\/\/research.fhcrc.org\/youyifong\/en\/resources\/ncal.html.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt456","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T04:52:16Z","timestamp":1375937536000},"page":"2653-2654","source":"Crossref","is-referenced-by-count":26,"title":["nCal: an R package for non-linear calibration"],"prefix":"10.1093","volume":"29","author":[{"given":"Youyi","family":"Fong","sequence":"first","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztian","family":"Sebestyen","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuesong","family":"Yu","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Self","sequence":"additional","affiliation":[{"name":"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,8,6]]},"reference":[{"key":"2023012810470268500_btt456-B1","volume-title":"Nonlinear models for repeated measurement data","author":"Davidian","year":"1995"},{"key":"2023012810470268500_btt456-B2","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/j.1541-0420.2012.01762.x","article-title":"A robust Bayesian random effects model for nonlinear calibration problems","volume":"68","author":"Fong","year":"2012","journal-title":"Biometrics"},{"key":"2023012810470268500_btt456-B3","article-title":"JAGS: a program for analysis of Bayesian graphical models using Gibbs sampling","volume-title":"Proceedings of the 3rd International Workshop on Distributed Statistical Computing","author":"Plummer","year":"2003"},{"key":"2023012810470268500_btt456-B4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v012.i05","article-title":"Bioassay analysis using R","volume":"12","author":"Ritz","year":"2005","journal-title":"J. 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