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RNAfdl is slow but capable of producing intersection-free diagrams for ribosome-sized structures, has a graphical user interface for adjustments and produces output in common formats.<\/jats:p>\n               <jats:p>Availability and implementation: Source code is available under the GNU General Public License v3.0 at http:\/\/sourceforge.net\/projects\/rnafdl for Linux and similar systems or Windows using MinGW. RNAfdl is implemented in C, uses the Cairo 2D graphics library and offers both command line and graphical user interfaces.<\/jats:p>\n               <jats:p>Contact: \u00a0hecker@rth.dk<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt496","type":"journal-article","created":{"date-parts":[[2013,8,24]],"date-time":"2013-08-24T04:09:42Z","timestamp":1377317382000},"page":"2941-2942","source":"Crossref","is-referenced-by-count":12,"title":["RNA secondary structure diagrams for very large molecules: RNAfdl"],"prefix":"10.1093","volume":"29","author":[{"given":"Nikolai","family":"Hecker","sequence":"first","affiliation":[{"name":"1 Centre for non-coding RNA in Technology and Health and 2Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark, 3European Molecular Biology Laboratory\u2014Hamburg Outstation, c\/o DESY, 22603 Hamburg, Germany and 4Centre for Bioinformatics, Institute for Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany"},{"name":"1 Centre for non-coding RNA in Technology and Health and 2Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark, 3European Molecular Biology Laboratory\u2014Hamburg Outstation, c\/o DESY, 22603 Hamburg, Germany and 4Centre for Bioinformatics, Institute for Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany"}]},{"given":"Tim","family":"Wiegels","sequence":"additional","affiliation":[{"name":"1 Centre for non-coding RNA in Technology and Health and 2Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark, 3European Molecular Biology Laboratory\u2014Hamburg Outstation, c\/o DESY, 22603 Hamburg, Germany and 4Centre for Bioinformatics, Institute for Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany"}]},{"given":"Andrew E.","family":"Torda","sequence":"additional","affiliation":[{"name":"1 Centre for non-coding RNA in Technology and Health and 2Department of Veterinary Clinical and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark, 3European Molecular Biology Laboratory\u2014Hamburg Outstation, c\/o DESY, 22603 Hamburg, Germany and 4Centre for Bioinformatics, Institute for Biochemistry and Molecular Biology, University of Hamburg, 20146 Hamburg, Germany"}]}],"member":"286","published-online":{"date-parts":[[2013,8,23]]},"reference":[{"key":"2023012810490274800_btt496-B1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/1471-2105-9-340","article-title":"RNA STRAND: the RNA secondary structure and statistical analysis database","volume":"9","author":"Andronescu","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"2023012810490274800_btt496-B2","first-page":"167","article-title":"An improved algorithm for nucleic acid secondary structure display","volume":"4","author":"Bruccoleri","year":"1988","journal-title":"Comput. 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