{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:45:32Z","timestamp":1740185132784,"version":"3.37.3"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"24","funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: It has been suggested that presumably distinct classes of genomic regulatory elements may actually share common sets of features and mechanisms. However, there has been no genome-wide assessment of the prevalence of this phenomenon.<\/jats:p>\n               <jats:p>Results: To evaluate this possibility, we performed a bioinformatic screen for the existence of compound regulatory elements in the human genome. We identified numerous such colocated boundary and enhancer elements from human CD4+ T cells. We report evidence that such compound regulatory elements possess unique chromatin features and facilitate cell type-specific functions related to inflammation and immune response in CD4+ T cells.<\/jats:p>\n               <jats:p>Contact: \u00a0king.jordan@biology.gatech.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt542","type":"journal-article","created":{"date-parts":[[2013,10,2]],"date-time":"2013-10-02T00:44:01Z","timestamp":1380674641000},"page":"3109-3112","source":"Crossref","is-referenced-by-count":1,"title":["Compound <i>cis<\/i>-regulatory elements with both boundary and enhancer sequences in the human genome"],"prefix":"10.1093","volume":"29","author":[{"given":"Daudi","family":"Jjingo","sequence":"first","affiliation":[{"name":"1 School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA, 2Buck Institute for Research on Aging, Novato, CA 94945, USA and 3PanAmerican Bioinformatics Institute, Santa Marta, Magdalena, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianrong","family":"Wang","sequence":"additional","affiliation":[{"name":"1 School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA, 2Buck Institute for Research on Aging, Novato, CA 94945, USA and 3PanAmerican Bioinformatics Institute, Santa Marta, Magdalena, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew B.","family":"Conley","sequence":"additional","affiliation":[{"name":"1 School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA, 2Buck Institute for Research on Aging, Novato, CA 94945, USA and 3PanAmerican Bioinformatics Institute, Santa Marta, Magdalena, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria V.","family":"Lunyak","sequence":"additional","affiliation":[{"name":"1 School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA, 2Buck Institute for Research on Aging, Novato, CA 94945, USA and 3PanAmerican Bioinformatics Institute, Santa Marta, Magdalena, Colombia"},{"name":"1 School of Biology, Georgia Institute of Technology, Atlanta, GA 30332, USA, 2Buck Institute for Research on Aging, Novato, CA 94945, USA and 3PanAmerican Bioinformatics Institute, Santa Marta, Magdalena, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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