{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:13:26Z","timestamp":1773371606941,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"24","funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Motivation: Novel tools need to be developed to help scientists analyze large amounts of available screening data with the goal to identify entry points for the development of novel chemical probes and drugs. As the largest class of drug targets, G protein-coupled receptors (GPCRs) remain of particular interest and are pursued by numerous academic and industrial research projects.<\/jats:p><jats:p>Results: We report the first GPCR ontology to facilitate integration and aggregation of GPCR-targeting drugs and demonstrate its application to classify and analyze a large subset of the PubChem database. The GPCR ontology, based on previously reported BioAssay Ontology, depicts available pharmacological, biochemical and physiological profiles of GPCRs and their ligands. The novelty of the GPCR ontology lies in the use of diverse experimental datasets linked by a model to formally define these concepts. Using a reasoning system, GPCR ontology offers potential for knowledge-based classification of individuals (such as small molecules) as a function of the data.<\/jats:p><jats:p>Availability: The GPCR ontology is available at http:\/\/www.bioassayontology.org\/bao_gpcr and the National Center for Biomedical Ontologies Web site.<\/jats:p><jats:p>Contact: \u00a0sschurer@med.miami.edu<\/jats:p><jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt565","type":"journal-article","created":{"date-parts":[[2013,9,30]],"date-time":"2013-09-30T00:08:14Z","timestamp":1380499694000},"page":"3211-3219","source":"Crossref","is-referenced-by-count":23,"title":["GPCR ontology: development and application of a G protein-coupled receptor pharmacology knowledge framework"],"prefix":"10.1093","volume":"29","author":[{"given":"Magdalena J.","family":"Przydzial","sequence":"first","affiliation":[{"name":"1 Center for Computational Science, University of Miami, Miami, FL 33136, USA and 2Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}]},{"given":"Barun","family":"Bhhatarai","sequence":"additional","affiliation":[{"name":"1 Center for Computational Science, University of Miami, Miami, FL 33136, USA and 2Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}]},{"given":"Amar","family":"Koleti","sequence":"additional","affiliation":[{"name":"1 Center for Computational Science, University of Miami, Miami, FL 33136, USA and 2Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}]},{"given":"Uma","family":"Vempati","sequence":"additional","affiliation":[{"name":"1 Center for Computational Science, University of Miami, Miami, FL 33136, USA and 2Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}]},{"given":"Stephan C.","family":"Sch\u00fcrer","sequence":"additional","affiliation":[{"name":"1 Center for Computational Science, University of Miami, Miami, FL 33136, USA and 2Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"},{"name":"1 Center for Computational Science, University of Miami, Miami, FL 33136, USA and 2Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA"}]}],"member":"286","published-online":{"date-parts":[[2013,9,29]]},"reference":[{"key":"2023012810480695700_btt565-B1","article-title":"BAOSearch: a semantic web application for biological screening and drug discovery research","volume-title":"Semantic Web Challenge, 9th International Semantic Web Conference (ISWC)","author":"Abeyruwan","year":"2010"},{"key":"2023012810480695700_btt565-B2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/bib\/bbp024","article-title":"Biological knowledge management: the emerging role of the Semantic Web technologies","volume":"10","author":"Antezana","year":"2009","journal-title":"Brief. 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