{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:41:54Z","timestamp":1761648114509},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":1074,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Methods for computational drug target identification use information from diverse information sources to predict or prioritize drug targets for known drugs. One set of resources that has been relatively neglected for drug repurposing is animal model phenotype.<\/jats:p>\n               <jats:p>Results: We investigate the use of mouse model phenotypes for drug target identification. To achieve this goal, we first integrate mouse model phenotypes and drug effects, and then systematically compare the phenotypic similarity between mouse models and drug effect profiles. We find a high similarity between phenotypes resulting from loss-of-function mutations and drug effects resulting from the inhibition of a protein through a drug action, and demonstrate how this approach can be used to suggest candidate drug targets.<\/jats:p>\n               <jats:p>Availability and implementation: Analysis code and supplementary data files are available on the project Web site at https:\/\/drugeffects.googlecode.com.<\/jats:p>\n               <jats:p>Contact: \u00a0leechuck@leechuck.de or roh25@aber.ac.uk<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt613","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T04:43:23Z","timestamp":1382676203000},"page":"719-725","source":"Crossref","is-referenced-by-count":34,"title":["Mouse model phenotypes provide information about human drug targets"],"prefix":"10.1093","volume":"30","author":[{"given":"Robert","family":"Hoehndorf","sequence":"first","affiliation":[{"name":"1 Department of Computer Science, University of Aberystwyth, Old College, King Street, Aberystwyth SY23 2AX, 2Department of Biology, Institute of Biochemistry and School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada and 3Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Hiebert","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, University of Aberystwyth, Old College, King Street, Aberystwyth SY23 2AX, 2Department of Biology, Institute of Biochemistry and School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada and 3Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel W.","family":"Hardy","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, University of Aberystwyth, Old College, King Street, Aberystwyth SY23 2AX, 2Department of Biology, Institute of Biochemistry and School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada and 3Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul N.","family":"Schofield","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, University of Aberystwyth, Old College, King Street, Aberystwyth SY23 2AX, 2Department of Biology, Institute of Biochemistry and School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada and 3Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios V.","family":"Gkoutos","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, University of Aberystwyth, Old College, King Street, Aberystwyth SY23 2AX, 2Department of Biology, Institute of Biochemistry and School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada and 3Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Dumontier","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science, University of Aberystwyth, Old College, King Street, Aberystwyth SY23 2AX, 2Department of Biology, Institute of Biochemistry and School of Computer Science, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada and 3Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,10,24]]},"reference":[{"key":"2023012710432007600_btt613-B1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1124\/mol.61.1.7","article-title":"Diclofenac antagonizes peroxisome proliferator-activated receptor-\u03b3 signaling","volume":"61","author":"Adamson","year":"2002","journal-title":"Mol. 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