{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:05:30Z","timestamp":1773792330299,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Phosphorylation plays an important role in cellular signal transduction. Current phosphorylation-related databases often focus on the phosphorylation sites, which are mainly determined by mass spectrometry. Here, we present PhosphoNetworks, a phosphorylation database built on a high-resolution map of phosphorylation networks. This high-resolution map of phosphorylation networks provides not only the kinase\u2013substrate relationships (KSRs), but also the specific phosphorylation sites on which the kinases act on the substrates. The database contains the most comprehensive dataset for KSRs, including the relationships from a recent high-throughput project for identification of KSRs using protein microarrays, as well as known KSRs curated from the literature. In addition, the database also includes several analytical tools for dissecting phosphorylation networks. PhosphoNetworks is expected to play a prominent role in proteomics and phosphorylation-related disease research.<\/jats:p>\n               <jats:p>Availability and implementation: \u00a0http:\/\/www.phosphonetworks.org<\/jats:p>\n               <jats:p>Contact: \u00a0jiang.qian@jhmi.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt627","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T01:41:34Z","timestamp":1384393294000},"page":"141-142","source":"Crossref","is-referenced-by-count":111,"title":["PhosphoNetworks: a database for human phosphorylation networks"],"prefix":"10.1093","volume":"30","author":[{"given":"Jianfei","family":"Hu","sequence":"first","affiliation":[{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Sool","family":"Rho","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"},{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Newman","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"},{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"},{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhu","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"},{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"},{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Qian","sequence":"additional","affiliation":[{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"},{"name":"1 Department of Ophthalmology, Johns Hopkins School of Medicine, 2Department of Pharmacology and Molecular Sciences, 3Center for High-Throughput Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA, 4Department of Biology, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA and 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,11,13]]},"reference":[{"key":"2023012710375356100_btt627-B1","first-page":"5001","article-title":"The role of protein phosphorylation in human health and 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