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Despite that many reverse engineering tools have been designed, the Cascade package is an integrated solution adding several new and original key features such as the ability to predict changes in gene expressions after a biological perturbation in the network and graphical outputs that allow monitoring the spread of a signal through the network.<\/jats:p>\n               <jats:p>Availability and implementation: The R package Cascade is available online at http:\/\/www-math.u-strasbg.fr\/genpred\/spip.php?rubrique4.<\/jats:p>\n               <jats:p>Contact: \u00a0fbertran@math.unistra.fr<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt705","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T02:39:46Z","timestamp":1386211186000},"page":"571-573","source":"Crossref","is-referenced-by-count":9,"title":["Cascade: a R package to study, predict and simulate the diffusion of a signal through a temporal gene network"],"prefix":"10.1093","volume":"30","author":[{"given":"Nicolas","family":"Jung","sequence":"first","affiliation":[{"name":"1 INSERM UMR S_1109, Labex Transplantex, FMTS, H\u00f4pitaux and Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Strasbourg, 67085 Strasbourg Cedex and 2IRMA, CNRS UMR 7501, Labex IRMIA, Universit\u00e9 de Strasbourg, 67084 Strasbourg Cedex, France"},{"name":"1 INSERM UMR S_1109, Labex Transplantex, FMTS, H\u00f4pitaux and Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Strasbourg, 67085 Strasbourg Cedex and 2IRMA, CNRS UMR 7501, Labex IRMIA, Universit\u00e9 de Strasbourg, 67084 Strasbourg Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Bertrand","sequence":"additional","affiliation":[{"name":"1 INSERM UMR S_1109, Labex Transplantex, FMTS, H\u00f4pitaux and Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Strasbourg, 67085 Strasbourg Cedex and 2IRMA, CNRS UMR 7501, Labex IRMIA, Universit\u00e9 de Strasbourg, 67084 Strasbourg Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiamak","family":"Bahram","sequence":"additional","affiliation":[{"name":"1 INSERM UMR S_1109, Labex Transplantex, FMTS, H\u00f4pitaux and Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Strasbourg, 67085 Strasbourg Cedex and 2IRMA, CNRS UMR 7501, Labex IRMIA, Universit\u00e9 de Strasbourg, 67084 Strasbourg Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Vallat","sequence":"additional","affiliation":[{"name":"1 INSERM UMR S_1109, Labex Transplantex, FMTS, H\u00f4pitaux and Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Strasbourg, 67085 Strasbourg Cedex and 2IRMA, CNRS UMR 7501, Labex IRMIA, Universit\u00e9 de Strasbourg, 67084 Strasbourg Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Maumy-Bertrand","sequence":"additional","affiliation":[{"name":"1 INSERM UMR S_1109, Labex Transplantex, FMTS, H\u00f4pitaux and Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Strasbourg, 67085 Strasbourg Cedex and 2IRMA, CNRS UMR 7501, Labex IRMIA, Universit\u00e9 de Strasbourg, 67084 Strasbourg Cedex, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,12,3]]},"reference":[{"key":"2023012710425274200_btt705-B1","first-page":"69","article-title":"Emergence of scaling in complex networks","volume-title":"Handbook of Graphs and Networks: From the Genome to the Internet","author":"Barab\u00e1si","year":"2003"},{"key":"2023012710425274200_btt705-B2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrg3244","article-title":"Studying and modelling dynamic biological processes using time-series gene expression data","volume":"13","author":"Bar-Joseph","year":"2012","journal-title":"Nat. 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