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The software incorporates advanced cheminformatics capabilities such as chemical structure storage and visualization, fast similarity search and chemical neighborhood analysis for retrieved hits. The software is freely available for academic laboratories.<\/jats:p>\n               <jats:p>Availability and implementation: \u00a0http:\/\/fourches.web.unc.edu\/<\/jats:p>\n               <jats:p>Contact: \u00a0fourches@email.unc.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btt718","type":"journal-article","created":{"date-parts":[[2013,12,29]],"date-time":"2013-12-29T01:20:23Z","timestamp":1388280023000},"page":"588-589","source":"Crossref","is-referenced-by-count":17,"title":["HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data"],"prefix":"10.1093","volume":"30","author":[{"given":"Denis","family":"Fourches","sequence":"first","affiliation":[{"name":"1 Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill and 2Department of Pharmacology and the NIMH Psychoactive Drug Screening Program, School of Medicine, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria F.","family":"Sassano","sequence":"additional","affiliation":[{"name":"1 Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill and 2Department of Pharmacology and the NIMH Psychoactive Drug Screening Program, School of Medicine, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan L.","family":"Roth","sequence":"additional","affiliation":[{"name":"1 Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill and 2Department of Pharmacology and the NIMH Psychoactive Drug Screening Program, School of Medicine, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Tropsha","sequence":"additional","affiliation":[{"name":"1 Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill and 2Department of Pharmacology and the NIMH Psychoactive Drug Screening Program, School of Medicine, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,12,28]]},"reference":[{"key":"2023012710422306700_btt718-B1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/minf.201300076","article-title":"Using graph indices for the analysis and comparison of chemical datasets","volume":"32","author":"Fourches","year":"2013","journal-title":"Mol. 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