{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:09:15Z","timestamp":1777511355032,"version":"3.51.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: The regulation of protein activity is a key aspect of life at the molecular level. Unveiling its details is thus crucial to understanding signalling and metabolic pathways. The most common and powerful mechanism of protein-function regulation is allostery, which has been increasingly calling the attention of medicinal chemists due to its potential for the discovery of novel therapeutics. In this context, PARS is a simple and fast method that queries protein dynamics and structural conservation to identify pockets on a protein structure that may exert a regulatory effect on the binding of a small-molecule ligand.<\/jats:p>\n               <jats:p>Availability: PARS is freely available as a web server at http:\/\/bioinf.uab.cat\/pars.<\/jats:p>\n               <jats:p>Contact: \u00a0xavier.daura@uab.cat<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu002","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T02:06:09Z","timestamp":1389405969000},"page":"1314-1315","source":"Crossref","is-referenced-by-count":127,"title":["PARS: a web server for the prediction of Protein Allosteric and Regulatory Sites"],"prefix":"10.1093","volume":"30","author":[{"given":"Alejandro","family":"Panjkovich","sequence":"first","affiliation":[{"name":"1 Institute of Biotechnology and Biomedicine (IBB), Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra 08193, Spain and 2Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Daura","sequence":"additional","affiliation":[{"name":"1 Institute of Biotechnology and Biomedicine (IBB), Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra 08193, Spain and 2Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain"},{"name":"1 Institute of Biotechnology and Biomedicine (IBB), Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra 08193, Spain and 2Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,1,9]]},"reference":[{"key":"2023012710502358800_btu002-B1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nbt.1598","article-title":"Design of phosphodiesterase 4d (PDE4D) allosteric modulators for enhancing cognition with improved safety","volume":"28","author":"Burgin","year":"2010","journal-title":"Nat. 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