{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:39:30Z","timestamp":1768991970345,"version":"3.49.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Elucidation of molecular targets of a compound [mode of action (MoA)] and its off-targets is a crucial step in drug development. We developed an online collaborative resource (MANTRA 2.0) that supports this process by exploiting similarities between drug-induced transcriptional profiles. Drugs are organized in a network of nodes (drugs) and edges (similarities) highlighting \u2018communities\u2019 of drugs sharing a similar MoA. A user can upload gene expression profiles before and after drug treatment in one or multiple cell types. An automated processing pipeline transforms the gene expression profiles into a unique drug \u2018node\u2019 embedded in the drug-network. Visual inspection of the neighbouring drugs and communities helps in revealing its MoA and to suggest new applications of known drugs (drug repurposing). MANTRA 2.0 allows storing and sharing user-generated network nodes, thus making MANTRA 2.0 a collaborative ever-growing resource.<\/jats:p>\n               <jats:p>Availability and implementation: The web tool is freely available for academic use at http:\/\/mantra.tigem.it.<\/jats:p>\n               <jats:p>Contact: \u00a0dibernardo@tigem.it<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu058","type":"journal-article","created":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T06:06:34Z","timestamp":1392962794000},"page":"1787-1788","source":"Crossref","is-referenced-by-count":76,"title":["Mantra 2.0: an online collaborative resource for drug mode of action and repurposing by network analysis"],"prefix":"10.1093","volume":"30","author":[{"given":"Diego","family":"Carrella","sequence":"first","affiliation":[{"name":"1 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, 2Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, 3Dip. di Studi Aziendali e Quantitativi Universit\u00e0 degli studi di Napoli \u2018Parthenope\u2019, Via Generale Parisi 13, 80132 Naples, 4Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples and 5Department of Electrical Engineering and Information Technology, University of Naples \u2018Federico II\u2019, Via Claudio 21, 80125 Naples, Italy"}]},{"given":"Francesco","family":"Napolitano","sequence":"additional","affiliation":[{"name":"1 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, 2Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, 3Dip. di Studi Aziendali e Quantitativi Universit\u00e0 degli studi di Napoli \u2018Parthenope\u2019, Via Generale Parisi 13, 80132 Naples, 4Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples and 5Department of Electrical Engineering and Information Technology, University of Naples \u2018Federico II\u2019, Via Claudio 21, 80125 Naples, Italy"}]},{"given":"Rossella","family":"Rispoli","sequence":"additional","affiliation":[{"name":"1 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, 2Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, 3Dip. di Studi Aziendali e Quantitativi Universit\u00e0 degli studi di Napoli \u2018Parthenope\u2019, Via Generale Parisi 13, 80132 Naples, 4Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples and 5Department of Electrical Engineering and Information Technology, University of Naples \u2018Federico II\u2019, Via Claudio 21, 80125 Naples, Italy"}]},{"given":"Mario","family":"Miglietta","sequence":"additional","affiliation":[{"name":"1 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, 2Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, 3Dip. di Studi Aziendali e Quantitativi Universit\u00e0 degli studi di Napoli \u2018Parthenope\u2019, Via Generale Parisi 13, 80132 Naples, 4Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples and 5Department of Electrical Engineering and Information Technology, University of Naples \u2018Federico II\u2019, Via Claudio 21, 80125 Naples, Italy"}]},{"given":"Annamaria","family":"Carissimo","sequence":"additional","affiliation":[{"name":"1 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, 2Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, 3Dip. di Studi Aziendali e Quantitativi Universit\u00e0 degli studi di Napoli \u2018Parthenope\u2019, Via Generale Parisi 13, 80132 Naples, 4Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples and 5Department of Electrical Engineering and Information Technology, University of Naples \u2018Federico II\u2019, Via Claudio 21, 80125 Naples, Italy"}]},{"given":"Luisa","family":"Cutillo","sequence":"additional","affiliation":[{"name":"1 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, 2Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, 3Dip. di Studi Aziendali e Quantitativi Universit\u00e0 degli studi di Napoli \u2018Parthenope\u2019, Via Generale Parisi 13, 80132 Naples, 4Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples and 5Department of Electrical Engineering and Information Technology, University of Naples \u2018Federico II\u2019, Via Claudio 21, 80125 Naples, Italy"},{"name":"1 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, 2Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, 3Dip. di Studi Aziendali e Quantitativi Universit\u00e0 degli studi di Napoli \u2018Parthenope\u2019, Via Generale Parisi 13, 80132 Naples, 4Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples and 5Department of Electrical Engineering and Information Technology, University of Naples \u2018Federico II\u2019, Via Claudio 21, 80125 Naples, Italy"}]},{"given":"Francesco","family":"Sirci","sequence":"additional","affiliation":[{"name":"1 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, 2Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, 3Dip. di Studi Aziendali e Quantitativi Universit\u00e0 degli studi di Napoli \u2018Parthenope\u2019, Via Generale Parisi 13, 80132 Naples, 4Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples and 5Department of Electrical Engineering and Information Technology, University of Naples \u2018Federico II\u2019, Via Claudio 21, 80125 Naples, Italy"}]},{"given":"Francesco","family":"Gregoretti","sequence":"additional","affiliation":[{"name":"1 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, 2Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, 3Dip. di Studi Aziendali e Quantitativi Universit\u00e0 degli studi di Napoli \u2018Parthenope\u2019, Via Generale Parisi 13, 80132 Naples, 4Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples and 5Department of Electrical Engineering and Information Technology, University of Naples \u2018Federico II\u2019, Via Claudio 21, 80125 Naples, Italy"}]},{"given":"Diego","family":"Di Bernardo","sequence":"additional","affiliation":[{"name":"1 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, 2Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, 3Dip. di Studi Aziendali e Quantitativi Universit\u00e0 degli studi di Napoli \u2018Parthenope\u2019, Via Generale Parisi 13, 80132 Naples, 4Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples and 5Department of Electrical Engineering and Information Technology, University of Naples \u2018Federico II\u2019, Via Claudio 21, 80125 Naples, Italy"},{"name":"1 Telethon Institute of Genetics and Medicine, Via P. Castellino 111, 80131 Naples, 2Interactive SRL, Via Fratelli Bisogno 5, 83100 Avellino, 3Dip. di Studi Aziendali e Quantitativi Universit\u00e0 degli studi di Napoli \u2018Parthenope\u2019, Via Generale Parisi 13, 80132 Naples, 4Institute for High-Performance Computing - ICAR - CNR, Via P. Castellino 111, 80131 Naples and 5Department of Electrical Engineering and Information Technology, University of Naples \u2018Federico II\u2019, Via Claudio 21, 80125 Naples, Italy"}]}],"member":"286","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"key":"2023012711074150100_btu058-B1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/bioinformatics\/17.6.509","article-title":"A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes","volume":"17","author":"Baldi","year":"2001","journal-title":"Bioinformatics"},{"key":"2023012711074150100_btu058-B2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy\u2014analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"2023012711074150100_btu058-B3","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1093\/bioinformatics\/bti696","article-title":"Medusa: a simple tool for interaction graph analysis","volume":"21","author":"Hooper","year":"2005","journal-title":"Bioinformatics"},{"key":"2023012711074150100_btu058-B4","doi-asserted-by":"crossref","first-page":"14621","DOI":"10.1073\/pnas.1000138107","article-title":"Discovery of drug mode of action and drug repositioning from transcriptional responses","volume":"107","author":"Iorio","year":"2010","journal-title":"Proc. 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