{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T07:02:25Z","timestamp":1772089345409,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The reasons for distortions from optimal \u03b1-helical geometry are widely unknown, but their influences on structural changes of proteins are significant. Hence, their prediction is a crucial problem in structural bioinformatics. Here, we present a new web server, called SKINK, for string kernel based kink prediction. Extending our previous study, we also annotate the most probable kink position in a given \u03b1-helix sequence.<\/jats:p>\n               <jats:p>Availability and implementation: The SKINK web server is freely accessible at http:\/\/biows-inf.zdv.uni-mainz.de\/skink. Moreover, SKINK is a module of the BALL software, also freely available at www.ballview.org.<\/jats:p>\n               <jats:p>Contact: \u00a0benny.kneissl@roche.com<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu096","type":"journal-article","created":{"date-parts":[[2014,2,15]],"date-time":"2014-02-15T02:04:22Z","timestamp":1392429862000},"page":"1769-1770","source":"Crossref","is-referenced-by-count":2,"title":["SKINK: a web server for string kernel based kink prediction in \u03b1-helices"],"prefix":"10.1093","volume":"30","author":[{"given":"Tim","family":"Seifert","sequence":"first","affiliation":[{"name":"1 Department of Software Engineering and Bioinformatics, Johannes Gutenberg University of Mainz, 55128 Mainz, 2Institute for Computer Science, Johann Wolfgang Goethe-University Frankfurt am Main, 60054 Frankfurt am Main, 3Data Science, Pharma Research and Early Development Informatics (pREDi), Roche Diagnostics GmbH, 82377 Penzberg, 4Department of Human Genetics, Saarland University Faculty of Medicine, 66421 Homburg and 5Lead Identification and Optimization Support, Boehringer-Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany"}]},{"given":"Andreas","family":"Lund","sequence":"additional","affiliation":[{"name":"1 Department of Software Engineering and Bioinformatics, Johannes Gutenberg University of Mainz, 55128 Mainz, 2Institute for Computer Science, Johann Wolfgang Goethe-University Frankfurt am Main, 60054 Frankfurt am Main, 3Data Science, Pharma Research and Early Development Informatics (pREDi), Roche Diagnostics GmbH, 82377 Penzberg, 4Department of Human Genetics, Saarland University Faculty of Medicine, 66421 Homburg and 5Lead Identification and Optimization Support, Boehringer-Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany"}]},{"given":"Benny","family":"Kneissl","sequence":"additional","affiliation":[{"name":"1 Department of Software Engineering and Bioinformatics, Johannes Gutenberg University of Mainz, 55128 Mainz, 2Institute for Computer Science, Johann Wolfgang Goethe-University Frankfurt am Main, 60054 Frankfurt am Main, 3Data Science, Pharma Research and Early Development Informatics (pREDi), Roche Diagnostics GmbH, 82377 Penzberg, 4Department of Human Genetics, Saarland University Faculty of Medicine, 66421 Homburg and 5Lead Identification and Optimization Support, Boehringer-Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany"}]},{"given":"Sabine C.","family":"Mueller","sequence":"additional","affiliation":[{"name":"1 Department of Software Engineering and Bioinformatics, Johannes Gutenberg University of Mainz, 55128 Mainz, 2Institute for Computer Science, Johann Wolfgang Goethe-University Frankfurt am Main, 60054 Frankfurt am Main, 3Data Science, Pharma Research and Early Development Informatics (pREDi), Roche Diagnostics GmbH, 82377 Penzberg, 4Department of Human Genetics, Saarland University Faculty of Medicine, 66421 Homburg and 5Lead Identification and Optimization Support, Boehringer-Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany"}]},{"given":"Christofer S.","family":"Tautermann","sequence":"additional","affiliation":[{"name":"1 Department of Software Engineering and Bioinformatics, Johannes Gutenberg University of Mainz, 55128 Mainz, 2Institute for Computer Science, Johann Wolfgang Goethe-University Frankfurt am Main, 60054 Frankfurt am Main, 3Data Science, Pharma Research and Early Development Informatics (pREDi), Roche Diagnostics GmbH, 82377 Penzberg, 4Department of Human Genetics, Saarland University Faculty of Medicine, 66421 Homburg and 5Lead Identification and Optimization Support, Boehringer-Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany"}]},{"given":"Andreas","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"1 Department of Software Engineering and Bioinformatics, Johannes Gutenberg University of Mainz, 55128 Mainz, 2Institute for Computer Science, Johann Wolfgang Goethe-University Frankfurt am Main, 60054 Frankfurt am Main, 3Data Science, Pharma Research and Early Development Informatics (pREDi), Roche Diagnostics GmbH, 82377 Penzberg, 4Department of Human Genetics, Saarland University Faculty of Medicine, 66421 Homburg and 5Lead Identification and Optimization Support, Boehringer-Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany"}]}],"member":"286","published-online":{"date-parts":[[2014,2,14]]},"reference":[{"key":"2023012711063855800_btu096-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1145\/1961189.1961199","article-title":"LIBSVM: a library for support vector machines","volume":"27","author":"Chang","year":"2011","journal-title":"ACM Trans. Intell. Syst. Technol."},{"key":"2023012711063855800_btu096-B2","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.jmgm.2009.02.004","article-title":"Position of helical kinks in membrane protein crystal structures and the accuracy of computational prediction","volume":"27","author":"Hall","year":"2009","journal-title":"J. Mol. Graph. Model."},{"key":"2023012711063855800_btu096-B3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/1471-2105-11-531","article-title":"BALL\u2013Biochemical Algorithms Library 1.3","volume":"11","author":"Hildebrandt","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2023012711063855800_btu096-B4","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1021\/ci200278w","article-title":"String kernels and high-quality data set for improved prediction of kinked helices in \u03b1-helical membrane proteins","volume":"51","author":"Kneissl","year":"2011","journal-title":"J. Chem. Inf. 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