{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:17:39Z","timestamp":1774689459224,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,15]]},"abstract":"<jats:p>Summary: We developed new software environment for the metabolome analysis of large-scale multiple reaction monitoring (MRM) assays. It supports the data format of four major mass spectrometer vendors and mzML common data format. This program provides a process pipeline from the raw-format import to high-dimensional statistical analyses. The novel aspect is graphical user interface-based visualization to perform peak quantification, to interpolate missing values and to normalize peaks interactively based on quality control samples. Together with the software platform, the MRM standard library of 301 metabolites with 775 transitions is also available, which contributes to the reliable peak identification by using retention time and ion abundances.<\/jats:p>\n               <jats:p>Availability and implementation: MRMPROBS is available for Windows OS under the creative-commons by-attribution license at http:\/\/prime.psc.riken.jp.<\/jats:p>\n               <jats:p>Contact: \u00a0hiroshi.tsugawa@riken.jp<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary Data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu203","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:28:11Z","timestamp":1398126491000},"page":"2379-2380","source":"Crossref","is-referenced-by-count":84,"title":["MRMPROBS suite for metabolomics using large-scale MRM assays"],"prefix":"10.1093","volume":"30","author":[{"given":"Hiroshi","family":"Tsugawa","sequence":"first","affiliation":[{"name":"1 \u00a01RIKEN Center for Sustainable Resource Science, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan 2Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan 3Reifycs Incorporated, 1-6-12 Nishishinbashi, Minato-ku, Tokyo 105-0003, Japan and 4National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan"}]},{"given":"Mitsuhiro","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"1 \u00a01RIKEN Center for Sustainable Resource Science, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan 2Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan 3Reifycs Incorporated, 1-6-12 Nishishinbashi, Minato-ku, Tokyo 105-0003, Japan and 4National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan"}]},{"given":"Atsushi","family":"Ogiwara","sequence":"additional","affiliation":[{"name":"1 \u00a01RIKEN Center for Sustainable Resource Science, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan 2Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan 3Reifycs Incorporated, 1-6-12 Nishishinbashi, Minato-ku, Tokyo 105-0003, Japan and 4National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan"}]},{"given":"Masanori","family":"Arita","sequence":"additional","affiliation":[{"name":"1 \u00a01RIKEN Center for Sustainable Resource Science, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan 2Department of Biotechnology, Graduate School of Engineering, Osaka University, Suita, Osaka 565-0871, Japan 3Reifycs Incorporated, 1-6-12 Nishishinbashi, Minato-ku, Tokyo 105-0003, Japan and 4National Institute of Genetics, Mishima, Shizuoka 411-8540, Japan"}]}],"member":"286","published-online":{"date-parts":[[2014,4,20]]},"reference":[{"key":"2023012711523378900_btu203-B1","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. 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