{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:40:08Z","timestamp":1775608808472,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: We created a deeply extracted and annotated database of genome-wide association studies (GWAS) results. GRASP v1.0 contains &amp;gt;6.2 million SNP-phenotype association from among 1390 GWAS studies. We re-annotated GWAS results with 16 annotation sources including some rarely compared to GWAS results (e.g. RNAediting sites, lincRNAs, PTMs).<\/jats:p>\n               <jats:p>Motivation: To create a high-quality resource to facilitate further use and interpretation of human GWAS results in order to address important scientific questions.<\/jats:p>\n               <jats:p>Results: GWAS have grown exponentially, with increases in sample sizes and markers tested, and continuing bias toward European ancestry samples. GRASP contains &amp;gt;100 000 phenotypes, roughly: eQTLs (71.5%), metabolite QTLs (21.2%), methylation QTLs (4.4%) and diseases, biomarkers and other traits (2.8%). cis-eQTLs, meQTLs, mQTLs and MHC region SNPs are highly enriched among significant results. After removing these categories, GRASP still contains a greater proportion of studies and results than comparable GWAS catalogs. Cardiovascular disease and related risk factors pre-dominate remaining GWAS results, followed by immunological, neurological and cancer traits. Significant results in GWAS display a highly gene-centric tendency. Sex chromosome X (OR = 0.18[0.16-0.20]) and Y (OR = 0.003[0.001-0.01]) genes are depleted for GWAS results. Gene length is correlated with GWAS results at nominal significance (P \u2264 0.05) levels. We show this gene-length correlation decays at increasingly more stringent P-value thresholds. Potential pleotropic genes and SNPs enriched for multi-phenotype association in GWAS are identified. However, we note possible population stratification at some of these loci. Finally, via re-annotation we identify compelling functional hypotheses at GWAS loci, in some cases unrealized in studies to date.<\/jats:p>\n               <jats:p>Conclusion: Pooling summary-level GWAS results and re-annotating with bioinformatics predictions and molecular features provides a good platform for new insights.<\/jats:p>\n               <jats:p>Availability: The GRASP database is available at http:\/\/apps.nhlbi.nih.gov\/grasp.<\/jats:p>\n               <jats:p>Contact: \u00a0johnsonad2@nhlbi.nih.gov<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu273","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T21:55:09Z","timestamp":1402955709000},"page":"i185-i194","source":"Crossref","is-referenced-by-count":240,"title":["GRASP: analysis of genotype\u2013phenotype results from 1390 genome-wide association studies and corresponding open access database"],"prefix":"10.1093","volume":"30","author":[{"given":"Richard","family":"Leslie","sequence":"first","affiliation":[{"name":"1 Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, 2University of Massachusetts Medical School, Worcester, MA 01655 and 3Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"1 Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, 2University of Massachusetts Medical School, Worcester, MA 01655 and 3Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA"}]},{"given":"Christopher J.","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"1 Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, 2University of Massachusetts Medical School, Worcester, MA 01655 and 3Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"1 Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, 2University of Massachusetts Medical School, Worcester, MA 01655 and 3Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA"}]},{"given":"Andrew D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"1 Cardiovascular Epidemiology and Human Genomics Branch, National Heart, Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702, 2University of Massachusetts Medical School, Worcester, MA 01655 and 3Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA"}]}],"member":"286","published-online":{"date-parts":[[2014,6,11]]},"reference":[{"key":"2023012711072407500_btu273-B1","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/ng.241","article-title":"EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa","volume":"40","author":"Abd El-Aziz","year":"2008","journal-title":"Nat. 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Hered."},{"key":"2023012711072407500_btu273-B40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.tig.2009.09.012","article-title":"Next generation disparities in human genomics: concerns and remedies","volume":"25","author":"Need","year":"2009","journal-title":"Trends Genet."},{"key":"2023012711072407500_btu273-B41","doi-asserted-by":"crossref","first-page":"D1036","DOI":"10.1093\/nar\/gkr899","article-title":"DistiLD Database: diseases and traits in linkage disequilibrium blocks","volume":"40","author":"Palleja","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2023012711072407500_btu273-B42","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00439-008-0582-9","article-title":"Genomewide association study for susceptibility genes contributing to familial Parkinson disease","volume":"124","author":"Pankratz","year":"2009","journal-title":"Hum. Genet."},{"key":"2023012711072407500_btu273-B43","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","article-title":"LocusZoom: regional visualization of genome-wide association scan results","volume":"26","author":"Pruim","year":"2010","journal-title":"Bioinformatics."},{"key":"2023012711072407500_btu273-B44","doi-asserted-by":"crossref","first-page":"rs3","DOI":"10.1126\/scisignal.2001570","article-title":"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation","volume":"4","author":"Rigbolt","year":"2011","journal-title":"Sci. Signal."},{"key":"2023012711072407500_btu273-B45","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1093\/hmg\/ddq497","article-title":"Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population","volume":"20","author":"Saad","year":"2011","journal-title":"Hum. Mol. 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