{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:32:23Z","timestamp":1771659143493,"version":"3.50.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: MaxLink, a guilt-by-association network search algorithm, has been made available as a web resource and a stand-alone version. Based on a user-supplied list of query genes, MaxLink identifies and ranks genes that are tightly linked to the query list. This functionality can be used to predict potential disease genes from an initial set of genes with known association to a disease. The original algorithm, used to identify and rank novel genes potentially involved in cancer, has been updated to use a more statistically sound method for selection of candidate genes and made applicable to other areas than cancer. The algorithm has also been made faster by re-implementation in C++, and the Web site uses FunCoup 3.0 as the underlying network.<\/jats:p>\n               <jats:p>Availability and implementation: MaxLink is freely available at http:\/\/maxlink.sbc.su.se both as a web service and a stand-alone application for download.<\/jats:p>\n               <jats:p>Contact: \u00a0dimitri.guala@scilifelab.se<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary materials are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu344","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T01:26:07Z","timestamp":1400721967000},"page":"2689-2690","source":"Crossref","is-referenced-by-count":33,"title":["MaxLink: network-based prioritization of genes tightly linked to a disease seed set"],"prefix":"10.1093","volume":"30","author":[{"given":"Dimitri","family":"Guala","sequence":"first","affiliation":[{"name":"1 Stockholm Bioinformatics Centre, Science for Life Laboratory, SE-17121 Solna, 2 Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-11321, Sweden and 3 Swedish eScience Research Center, SE-10450 Stockholm, Sweden"},{"name":"1 Stockholm Bioinformatics Centre, Science for Life Laboratory, SE-17121 Solna, 2 Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-11321, Sweden and 3 Swedish eScience Research Center, SE-10450 Stockholm, Sweden"}]},{"given":"Erik","family":"Sj\u00f6lund","sequence":"additional","affiliation":[{"name":"1 Stockholm Bioinformatics Centre, Science for Life Laboratory, SE-17121 Solna, 2 Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-11321, Sweden and 3 Swedish eScience Research Center, SE-10450 Stockholm, Sweden"},{"name":"1 Stockholm Bioinformatics Centre, Science for Life Laboratory, SE-17121 Solna, 2 Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-11321, Sweden and 3 Swedish eScience Research Center, SE-10450 Stockholm, Sweden"}]},{"given":"Erik L. L.","family":"Sonnhammer","sequence":"additional","affiliation":[{"name":"1 Stockholm Bioinformatics Centre, Science for Life Laboratory, SE-17121 Solna, 2 Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-11321, Sweden and 3 Swedish eScience Research Center, SE-10450 Stockholm, Sweden"},{"name":"1 Stockholm Bioinformatics Centre, Science for Life Laboratory, SE-17121 Solna, 2 Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-11321, Sweden and 3 Swedish eScience Research Center, SE-10450 Stockholm, Sweden"},{"name":"1 Stockholm Bioinformatics Centre, Science for Life Laboratory, SE-17121 Solna, 2 Department of Biochemistry and Biophysics, Stockholm University, Stockholm, SE-11321, Sweden and 3 Swedish eScience Research Center, SE-10450 Stockholm, Sweden"}]}],"member":"286","published-online":{"date-parts":[[2014,5,20]]},"reference":[{"key":"2023012711553285600_btu344-B1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/nar\/gkr1062","article-title":"Comparative interactomics with Funcoup 2.0","volume":"40","author":"Alexeyenko","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2023012711553285600_btu344-B2","first-page":"46","article-title":"[Orphanet, an information site on rare diseases]","author":"Aym\u00e9","year":"2003","journal-title":"Soins."},{"key":"2023012711553285600_btu344-B3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","article-title":"Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database","volume":"39","author":"Bertram","year":"2007","journal-title":"Nat. Genet."},{"key":"2023012711553285600_btu344-B4","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1093\/bioinformatics\/bts581","article-title":"An unbiased evaluation of gene prioritization tools","volume":"28","author":"B\u00f6rnigen","year":"2012","journal-title":"Bioinformatics"},{"key":"2023012711553285600_btu344-B5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0169-7552(98)00110-X","article-title":"The anatomy of a large-scale hypertextual Web search engine","volume":"30","author":"Brin","year":"1998","journal-title":"Comput. Networks ISDN Syst."},{"key":"2023012711553285600_btu344-B6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.pharmthera.2013.01.016","article-title":"Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review","volume":"138","author":"Csermely","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"2023012711553285600_btu344-B7","doi-asserted-by":"crossref","first-page":"D945","DOI":"10.1093\/nar\/gkq929","article-title":"COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer","volume":"39","author":"Forbes","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2023012711553285600_btu344-B8","first-page":"26","article-title":"GeneRanker: an online system for predicting gene-disease associations for translational research","volume":"2008","author":"Gonzalez","year":"2008","journal-title":"Summit Translat. Bioinforma."},{"key":"2023012711553285600_btu344-B9","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1093\/bioinformatics\/btn213","article-title":"jSquid: a Java applet for graphical on-line network exploration","volume":"24","author":"Klammer","year":"2008","journal-title":"Bioinformatics"},{"key":"2023012711553285600_btu344-B10","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ajhg.2008.02.013","article-title":"Walking the interactome for prioritization of candidate disease genes","volume":"82","author":"K\u00f6hler","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"2023012711553285600_btu344-B11","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1101\/gr.118992.110","article-title":"Prioritizing candidate disease genes by network-based boosting of genome-wide association data","volume":"21","author":"Lee","year":"2011","journal-title":"Genome Res."},{"key":"2023012711553285600_btu344-B12","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1186\/gb-2011-12-6-r57","article-title":"BioGraph: unsupervised biomedical knowledge discovery via automated hypothesis generation","volume":"12","author":"Liekens","year":"2011","journal-title":"Genome Biol."},{"key":"2023012711553285600_btu344-B13","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrg3253","article-title":"Computational tools for prioritizing candidate genes: boosting disease gene discovery","volume":"13","author":"Moreau","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"2023012711553285600_btu344-B14","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1074\/mcp.M900227-MCP200","article-title":"Network-based Identification of novel cancer genes","volume":"9","author":"\u00d6stlund","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"2023012711553285600_btu344-B15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jda.2007.08.003","article-title":"A generalization of Dijkstra\u2019s shortest path algorithm with applications to VLSI routing","volume":"7","author":"Peyer","year":"2009","journal-title":"J. Discrete Algorithms"},{"key":"2023012711553285600_btu344-B16","doi-asserted-by":"crossref","first-page":"D380","DOI":"10.1093\/nar\/gkt984","article-title":"FunCoup 3.0: database of genome-wide functional coupling networks","volume":"42","author":"Schmitt","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2023012711553285600_btu344-B17","doi-asserted-by":"crossref","first-page":"e3874","DOI":"10.1371\/journal.pone.0003874","article-title":"GeneDistiller\u2013distilling candidate genes from linkage intervals","volume":"3","author":"Seelow","year":"2008","journal-title":"PLoS One"},{"key":"2023012711553285600_btu344-B18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/bib\/bbq007","article-title":"A guide to web tools to prioritize candidate genes","volume":"12","author":"Tranchevent","year":"2011","journal-title":"Brief. Bioinform."},{"key":"2023012711553285600_btu344-B19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1186\/1471-2164-13-535","article-title":"GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases","volume":"13","author":"van Dam","year":"2012","journal-title":"BMC Genomics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/30\/18\/2689\/48929214\/bioinformatics_30_18_2689.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/30\/18\/2689\/48929214\/bioinformatics_30_18_2689.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T12:36:49Z","timestamp":1674823009000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/30\/18\/2689\/2475609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,20]]},"references-count":19,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2014,9,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btu344","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2014,9,15]]},"published":{"date-parts":[[2014,5,20]]}}}