{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:45:36Z","timestamp":1781531136976,"version":"3.54.5"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The emergence of network medicine not only offers more opportunities for better and more complete understanding of the molecular complexities of diseases, but also serves as a promising tool for identifying new drug targets and establishing new relationships among diseases that enable drug repositioning. Computational approaches for drug repositioning by integrating information from multiple sources and multiple levels have the potential to provide great insights to the complex relationships among drugs, targets, disease genes and diseases at a system level.<\/jats:p>\n               <jats:p>Results: In this article, we have proposed a computational framework based on a heterogeneous network model and applied the approach on drug repositioning by using existing omics data about diseases, drugs and drug targets. The novelty of the framework lies in the fact that the strength between a disease\u2013drug pair is calculated through an iterative algorithm on the heterogeneous graph that also incorporates drug-target information. Comprehensive experimental results show that the proposed approach significantly outperforms several recent approaches. Case studies further illustrate its practical usefulness .<\/jats:p>\n               <jats:p>Availability and implementation: \u00a0http:\/\/cbc.case.edu<\/jats:p>\n               <jats:p>Contact: \u00a0jingli@cwru.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu403","type":"journal-article","created":{"date-parts":[[2014,6,29]],"date-time":"2014-06-29T00:12:32Z","timestamp":1404000752000},"page":"2923-2930","source":"Crossref","is-referenced-by-count":321,"title":["Drug repositioning by integrating target information through a heterogeneous network model"],"prefix":"10.1093","volume":"30","author":[{"given":"Wenhui","family":"Wang","sequence":"first","affiliation":[{"name":"1 Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and 2 Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA"},{"name":"1 Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and 2 Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Yang","sequence":"additional","affiliation":[{"name":"1 Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and 2 Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"1 Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and 2 Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"1 Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, OH 44106, USA and 2 Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"2023012711555406800_btu403-B1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1176\/appi.psy.47.1.70","article-title":"Quetiapine in the treatment of behavioral disturbances in patients with Huntington's disease","volume":"47","author":"Alpay","year":"2006","journal-title":"Psychosomatics"},{"key":"2023012711555406800_btu403-B2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/79839","article-title":"Guilt by association","volume":"26","author":"Altshuler","year":"2000","journal-title":"Nat. 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