{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:33:44Z","timestamp":1771878824823,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":890,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Here we introduce cc SOL omics , a webserver for large-scale calculations of protein solubility. Our method allows (i) proteome-wide predictions; (ii) identification of soluble fragments within each sequences; (iii) exhaustive single-point mutation analysis.<\/jats:p>\n               <jats:p>Results: Using coil\/disorder, hydrophobicity, hydrophilicity, \u03b2-sheet and \u03b1-helix propensities, we built a predictor of protein solubility. Our approach shows an accuracy of 79% on the training set (36 990 Target Track entries). Validation on three independent sets indicates that ccSOL omics discriminates soluble and insoluble proteins with an accuracy of 74% on 31 760 proteins sharing &amp;lt;30% sequence similarity.<\/jats:p>\n               <jats:p>Availability and implementation: \u00a0cc SOL omics can be freely accessed on the web at http:\/\/s.tartaglialab.com\/page\/ccsol_group . Documentation and tutorial are available at http:\/\/s.tartaglialab.com\/static_files\/shared\/tutorial_ccsol_omics.html .<\/jats:p>\n               <jats:p>Contact: \u00a0gian.tartaglia@crg.es<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu420","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:27:22Z","timestamp":1404347242000},"page":"2975-2977","source":"Crossref","is-referenced-by-count":99,"title":["<i>cc<\/i>\n            SOL \n            <i>omics<\/i>\n            : a webserver for solubility prediction of endogenous and heterologous expression in \n            <i>Escherichia coli<\/i>"],"prefix":"10.1093","volume":"30","author":[{"given":"Federico","family":"Agostini","sequence":"first","affiliation":[{"name":"1 Gene Function and Evolution, Bioinformatics and Genomics, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain and 2 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"},{"name":"1 Gene Function and Evolution, Bioinformatics and Genomics, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain and 2 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Cirillo","sequence":"additional","affiliation":[{"name":"1 Gene Function and Evolution, Bioinformatics and Genomics, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain and 2 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"},{"name":"1 Gene Function and Evolution, Bioinformatics and Genomics, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain and 2 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Maria","family":"Livi","sequence":"additional","affiliation":[{"name":"1 Gene Function and Evolution, Bioinformatics and Genomics, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain and 2 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"},{"name":"1 Gene Function and Evolution, Bioinformatics and Genomics, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain and 2 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Delli Ponti","sequence":"additional","affiliation":[{"name":"1 Gene Function and Evolution, Bioinformatics and Genomics, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain and 2 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"},{"name":"1 Gene Function and Evolution, Bioinformatics and Genomics, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain and 2 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Gaetano","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"1 Gene Function and Evolution, Bioinformatics and Genomics, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain and 2 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"},{"name":"1 Gene Function and Evolution, Bioinformatics and Genomics, Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain and 2 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,6,1]]},"reference":[{"key":"2023012711554991000_btu420-B1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jmb.2011.12.005","article-title":"Sequence-based prediction of protein solubility","volume":"421","author":"Agostini","year":"2012","journal-title":"J. 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