{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:20:36Z","timestamp":1770740436227,"version":"3.49.0"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":832,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Non-targeted metabolomics technologies often yield data in which abundance for any given metabolite is observed and quantified for some samples and reported as missing for other samples. Apparent missingness can be due to true absence of the metabolite in the sample or presence at a level below detectability. Mixture-model analysis can formally account for metabolite \u2018missingness\u2019 due to absence or undetectability, but software for this type of analysis in the high-throughput setting is limited. The R package metabomxtr has been developed to facilitate mixture-model analysis of non-targeted metabolomics data in which only a portion of samples have quantifiable abundance for certain metabolites.<\/jats:p>\n               <jats:p>Availability and implementation: metabomxtr is available through Bioconductor. It is released under the GPL-2 license.<\/jats:p>\n               <jats:p>Contact: \u00a0dscholtens@northwestern.edu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu509","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:14:11Z","timestamp":1406679251000},"page":"3287-3288","source":"Crossref","is-referenced-by-count":23,"title":["Metabomxtr: an R package for mixture-model analysis of non-targeted metabolomics data"],"prefix":"10.1093","volume":"30","author":[{"given":"Michael","family":"Nodzenski","sequence":"first","affiliation":[{"name":"1 Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, 2 Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute and 3 Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27704 and 4 Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Muehlbauer","sequence":"additional","affiliation":[{"name":"1 Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, 2 Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute and 3 Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27704 and 4 Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Bain","sequence":"additional","affiliation":[{"name":"1 Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, 2 Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute and 3 Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27704 and 4 Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611"},{"name":"1 Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, 2 Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute and 3 Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27704 and 4 Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna C.","family":"Reisetter","sequence":"additional","affiliation":[{"name":"1 Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, 2 Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute and 3 Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27704 and 4 Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"William L.","family":"Lowe","sequence":"additional","affiliation":[{"name":"1 Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, 2 Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute and 3 Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27704 and 4 Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise M.","family":"Scholtens","sequence":"additional","affiliation":[{"name":"1 Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, 2 Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute and 3 Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27704 and 4 Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,7,29]]},"reference":[{"key":"2023012711594536100_btu509-B1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0169-7439(98)00010-0","article-title":"Improving the speed of multi-way algorithms. Part I. Tucker 3","volume":"42","author":"Andersson","year":"1998","journal-title":"Chemometr. Intell. Lab. Syst."},{"key":"2023012711594536100_btu509-B2","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1007\/s11306-011-0366-4","article-title":"Missing values in mass spectrometry based metabolomics: an undervalued step in the data processing pipeline","volume":"8","author":"Hrydziuszko","year":"2012","journal-title":"Metabolomics"},{"key":"2023012711594536100_btu509-B3","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1002\/jssc.200900152","article-title":"Analytical and statistical approaches to metabolomics research","volume":"32","author":"Issaq","year":"2009","journal-title":"J. Sep. Sci."},{"key":"2023012711594536100_btu509-B4","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.trac.2007.08.003","article-title":"Metabolomics technologies and metabolite identification","volume":"26","author":"Moco","year":"2007","journal-title":"Trends Analyt. Chem."},{"key":"2023012711594536100_btu509-B5","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.2307\/2533289","article-title":"A mixture model with detection limits for regression analyses of antibody response to vaccine","volume":"51","author":"Moulton","year":"1995","journal-title":"Biometrics"},{"key":"2023012711594536100_btu509-B6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2337\/dc13-0989","article-title":"Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy","volume":"37","author":"Scholtens","year":"2014","journal-title":"Diabetes Care"},{"key":"2023012711594536100_btu509-B7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0169-7439(01)00131-9","article-title":"Dealing with missing data part I","volume":"58","author":"Walczak","year":"2001","journal-title":"Chemometr. Intell. Lab."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/30\/22\/3287\/48931034\/bioinformatics_30_22_3287.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/30\/22\/3287\/48931034\/bioinformatics_30_22_3287.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T12:55:29Z","timestamp":1674824129000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/30\/22\/3287\/2390508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,29]]},"references-count":7,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2014,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btu509","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2014,11,15]]},"published":{"date-parts":[[2014,7,29]]}}}