{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:59:54Z","timestamp":1771001994306,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The precise quantification of intracellular metabolic flow rates is of fundamental importance in bio(techno)logy and medical research. The gold standard in the field is metabolic flux analysis (MFA) with 13 C-labeling experiments. 13 C-MFA workflows orchestrate several, mainly human-in-the-loop, software applications, integrating them with plenty of heterogeneous information. In practice, this had posed a major practical barrier for evaluating, interpreting and understanding isotopic data from carbon labeling experiments.<\/jats:p>\n               <jats:p>Results: Graphical modeling, interactive model exploration and visual data analysis are the key to overcome this limitation. We have developed a first-of-its-kind graphical tool suite providing scientists with an integrated software framework for all aspects of 13 C-MFA. Almost 30 modules (plug-ins) have been implemented for the Omix visualization software. Several advanced graphical workflows and ergonomic user interfaces support major domain-specific modeling and proofreading tasks. With that, the graphical suite is a productivity enhancing tool and an original educational training instrument supporting the adoption of 13 C-MFA applications in all life science fields.<\/jats:p>\n               <jats:p>Availability: The Omix Light Edition is freely available at http:\/\/www.omix-visualization.com<\/jats:p>\n               <jats:p>Contact: \u00a0k.noeh@fz-juelich.de , p.droste@omix-visualization.com<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu585","type":"journal-article","created":{"date-parts":[[2014,10,9]],"date-time":"2014-10-09T01:49:44Z","timestamp":1412819384000},"page":"346-354","source":"Crossref","is-referenced-by-count":26,"title":["Visual workflows for \n            13\n            C-metabolic flux analysis"],"prefix":"10.1093","volume":"31","author":[{"given":"Katharina","family":"N\u00f6h","sequence":"first","affiliation":[{"name":"Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, 52425 J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Droste","sequence":"additional","affiliation":[{"name":"Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, 52425 J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Wiechert","sequence":"additional","affiliation":[{"name":"Institute of Bio- and Geosciences, IBG-1: Biotechnology, Forschungszentrum J\u00fclich GmbH, 52425 J\u00fclich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"2023020116163583000_btu585-B1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ymben.2006.09.001","article-title":"Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions","volume":"9","author":"Antoniewicz","year":"2007","journal-title":"Metab. 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