{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:27:19Z","timestamp":1778876839407,"version":"3.51.4"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary : Protein function prediction (PFP) is an automated function prediction method that predicts Gene Ontology (GO) annotations for a protein sequence using distantly related sequences and contextual associations of GO terms. Extended similarity group (ESG) is another GO prediction algorithm that makes predictions based on iterative sequence database searches. Here, we provide interactive web servers for the PFP and ESG algorithms that are equipped with an effective visualization of the GO predictions in a hierarchical topology.<\/jats:p>\n               <jats:p>Availability : PFP\/ESG servers are freely available at http:\/\/kiharalab.org\/web\/pfp.php and http:\/\/kiharalab.org\/web\/esg.php , or access both at http:\/\/kiharalab.org\/pfp_esg.php<\/jats:p>\n               <jats:p>Contact : dkihara@purdue.edu<\/jats:p>\n               <jats:p>Supplementary information : Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu646","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T06:07:10Z","timestamp":1412230030000},"page":"271-272","source":"Crossref","is-referenced-by-count":21,"title":["PFP\/ESG: automated protein function prediction servers enhanced with Gene Ontology visualization tool"],"prefix":"10.1093","volume":"31","author":[{"given":"Ishita K.","family":"Khan","sequence":"first","affiliation":[{"name":"1 Department of Computer Science and 2 Department of Biological Science, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Wei","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science and 2 Department of Biological Science, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghana","family":"Chitale","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science and 2 Department of Biological Science, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kihara","sequence":"additional","affiliation":[{"name":"1 Department of Computer Science and 2 Department of Biological Science, Purdue University, West Lafayette, IN 47907, USA"},{"name":"1 Department of Computer Science and 2 Department of Biological Science, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,10,1]]},"reference":[{"key":"2023020116155857000_btu646-B1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2023020116155857000_btu646-B2","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btp309","article-title":"ESG: extended similarity group method for automated protein function prediction","volume":"25","author":"Chitale","year":"2009","journal-title":"Bioinformatics"},{"key":"2023020116155857000_btu646-B3","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1110\/ps.062153506","article-title":"Enhanced automated function prediction using distantly related sequences and contextual association by PFP","volume":"15","author":"Hawkins","year":"2006","journal-title":"Protein Sci."},{"key":"2023020116155857000_btu646-B4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/prot.22172","article-title":"PFP: automated prediction of Gene Ontology functional annotations with confidence scores using protein sequence data","volume":"74","author":"Hawkins","year":"2009","journal-title":"Proteins"},{"key":"2023020116155857000_btu646-B5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/prot.21651","article-title":"Assessment of predictions submitted for the CASP7 function prediction category","volume":"69","author":"L\u00f3pez","year":"2007","journal-title":"Proteins"},{"key":"2023020116155857000_btu646-B6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nmeth.2340","article-title":"A large-scale evaluation of computational protein function prediction","volume":"10","author":"Radivojac","year":"2013","journal-title":"Nat. Meth."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/31\/2\/271\/49012211\/bioinformatics_31_2_271.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/31\/2\/271\/49012211\/bioinformatics_31_2_271.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:16:50Z","timestamp":1675297010000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/31\/2\/271\/2366244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,1]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,1,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btu646","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2015,1,15]]},"published":{"date-parts":[[2014,10,1]]}}}