{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:11:33Z","timestamp":1762161093443},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The model bacterium Escherichia coli is among the best studied prokaryotes, yet nearly half of its proteins are still of unknown biological function. This is despite a wealth of available large-scale physical and genetic interaction data. To address this, we extended the GeneMANIA function prediction web application developed for model eukaryotes to support E.coli .<\/jats:p>\n               <jats:p>Results: We integrated 48 distinct E.coli functional interaction datasets and used the GeneMANIA algorithm to produce thousands of novel functional predictions and prioritize genes for further functional assays. Our analysis achieved cross-validation performance comparable to that reported for eukaryotic model organisms, and revealed new functions for previously uncharacterized genes in specific bioprocesses, including components required for cell adhesion, iron\u2013sulphur complex assembly and ribosome biogenesis. The GeneMANIA approach for network-based function prediction provides an innovative new tool for probing mechanisms underlying bacterial bioprocesses.<\/jats:p>\n               <jats:p>Contact: \u00a0gary.bader@utoronto.ca ; mohan.babu@uregina.ca<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu671","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T02:56:07Z","timestamp":1413341767000},"page":"306-310","source":"Crossref","is-referenced-by-count":37,"title":["Novel function discovery with GeneMANIA: a new integrated resource for gene function prediction in \n            <i>Escherichia coli<\/i>"],"prefix":"10.1093","volume":"31","author":[{"given":"James","family":"Vlasblom","sequence":"first","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Zuberi","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Arnold","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alla","family":"Gagarinova","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"},{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor","family":"Deineko","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwani","family":"Kumar","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"},{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Leung","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Rizzolo","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahram","family":"Samanfar","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Chang","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadhna","family":"Phanse","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashkan","family":"Golshani","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack F.","family":"Greenblatt","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"},{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walid A.","family":"Houry","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Emili","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"},{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quaid","family":"Morris","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"},{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Bader","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"},{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"},{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohan","family":"Babu","sequence":"additional","affiliation":[{"name":"1 Department of Biochemistry, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 2 Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada, 3 Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 4 Department of Computer Science, University of Regina, Regina, Saskatchewan S4S0A2, Canada, 5 Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada, 6 Department of Biology, Carleton University, Ottawa, Ontario K1S 5B6, Canada and 7 Department of Computer Science, University of Toronto, Toronto, Ontario M5S 3G4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,10,13]]},"reference":[{"key":"2023020116160333600_btu671-B1","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1101\/gr.087528.108","article-title":"Global networks of functional coupling in eukaryotes from comprehensive data integration","volume":"19","author":"Alexeyenko","year":"2009","journal-title":"Genome Res."},{"key":"2023020116160333600_btu671-B2","doi-asserted-by":"crossref","first-page":"D629","DOI":"10.1093\/nar\/gkn853","article-title":"EcID. 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