{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T14:25:06Z","timestamp":1702650306827},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:p>Summary: MOST (metabolic optimization and simulation tool) is a software package that implements GDBB (genetic design through branch and bound) in an intuitive user-friendly interface with excel-like editing functionality, as well as implementing FBA (flux balance analysis), and supporting systems biology markup language and comma-separated values files. GDBB is currently the fastest algorithm for finding gene knockouts predicted by FBA to increase production of desired products, but GDBB has only been available on a command line interface, which is difficult to use for those without programming knowledge, until the release of MOST.<\/jats:p>\n               <jats:p>Availability and implementation: MOST is distributed for free on the GNU General Public License. The software and full documentation are available at http:\/\/most.ccib.rutgers.edu\/.<\/jats:p>\n               <jats:p>Contact: \u00a0dslun@rutgers.edu.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu685","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T02:34:38Z","timestamp":1413599678000},"page":"610-611","source":"Crossref","is-referenced-by-count":7,"title":["MOST: a software environment for constraint-based metabolic modeling and strain design"],"prefix":"10.1093","volume":"31","author":[{"given":"James J.","family":"Kelley","sequence":"first","affiliation":[{"name":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anatoliy","family":"Lane","sequence":"additional","affiliation":[{"name":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Li","sequence":"additional","affiliation":[{"name":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brahmaji","family":"Mutthoju","sequence":"additional","affiliation":[{"name":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shay","family":"Maor","sequence":"additional","affiliation":[{"name":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Egen","sequence":"additional","affiliation":[{"name":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond S.","family":"Lun","sequence":"additional","affiliation":[{"name":"1 \u00a01Center for Computational and Integrative Biology and Department of Computer Science, Rutgers University, Camden, NJ 08102, USA and 2Phenomics and Bioinformatics Research Centre and School of Mathematics and Statistics, University of South Australia, Mawson Lakes, SA 5095, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,10,17]]},"reference":[{"key":"2023020108553546100_btu685-B1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1752-0509-6-8","article-title":"FAME, the flux analysis and modeling environment","volume":"6","author":"Boele","year":"2012","journal-title":"BMC Syst. 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