{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:47:56Z","timestamp":1773276476988,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,15]]},"abstract":"<jats:p>Summary: Drug side effects are one of the main health threats worldwide, and an important obstacle in drug development. Understanding how adverse reactions occur requires knowledge on drug mechanisms at the molecular level. Despite recent advances, the need for tools and methods that facilitate side effect anticipation still remains. Here, we present IntSide, a web server that integrates chemical and biological information to elucidate the molecular mechanisms underlying drug side effects. IntSide currently catalogs 1175 side effects caused by 996 drugs, associated with drug features divided into eight categories, belonging to either biology or chemistry. On the biological side, IntSide reports drug targets and off-targets, pathways, molecular functions and biological processes. From a chemical viewpoint, it includes molecular fingerprints, scaffolds and chemical entities. Finally, we also integrate additional biological data, such as protein interactions and disease-related genes, to facilitate mechanistic interpretations.<\/jats:p>\n               <jats:p>Availability and implementation: Our data and web resource are available online (http:\/\/intside.irbbarcelona.org\/).<\/jats:p>\n               <jats:p>Contact: \u00a0patrick.aloy@irbbarcelona.org<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary Data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu688","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T02:34:38Z","timestamp":1413599678000},"page":"612-613","source":"Crossref","is-referenced-by-count":28,"title":["IntSide: a web server for the chemical and biological examination of drug side effects"],"prefix":"10.1093","volume":"31","author":[{"given":"Teresa","family":"Juan-Blanco","sequence":"first","affiliation":[{"name":"1 \u00a01Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona) and 2Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain"}]},{"given":"Miquel","family":"Duran-Frigola","sequence":"additional","affiliation":[{"name":"1 \u00a01Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona) and 2Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain"}]},{"given":"Patrick","family":"Aloy","sequence":"additional","affiliation":[{"name":"1 \u00a01Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona) and 2Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA), Barcelona, Spain"}]}],"member":"286","published-online":{"date-parts":[[2014,11,17]]},"reference":[{"key":"2023020108553416400_btu688-B1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev-pharmtox-011112-140248","article-title":"Systems pharmacology to predict drug toxicity: integration across levels of biological organization","volume":"53","author":"Bai","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2023020108553416400_btu688-B2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1126\/science.1158140","article-title":"Drug target identification using side-effect similarity","volume":"321","author":"Campillos","year":"2008","journal-title":"Science"},{"key":"2023020108553416400_btu688-B3","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1021\/ci4000079","article-title":"Adverse drug events: database construction and in silico prediction","volume":"53","author":"Cheng","year":"2013","journal-title":"J. Chem. Inf. Model."},{"key":"2023020108553416400_btu688-B4","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.chembiol.2013.03.017","article-title":"Analysis of chemical and biological features yields mechanistic insights into drug side effects","volume":"20","author":"Duran-Frigola","year":"2013","journal-title":"Chem. Biol."},{"key":"2023020108553416400_btu688-B5","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/446975a","article-title":"When drugs go bad","volume":"446","author":"Giacomini","year":"2007","journal-title":"Nature"},{"key":"2023020108553416400_btu688-B6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/msb.2009.98","article-title":"A side effect resource to capture phenotypic effects of drugs","volume":"6","author":"Kuhn","year":"2010","journal-title":"Mol. Syst. Biol."},{"key":"2023020108553416400_btu688-B7","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1021\/ci300245q","article-title":"ToxAlerts: a Web server of structural alerts for toxic chemicals and compounds with potential adverse reactions","volume":"52","author":"Sushko","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"2023020108553416400_btu688-B8","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/S1359-6446(03)02888-5","article-title":"Idiosyncratic toxicity: the role of toxicophores and bioactivation","volume":"8","author":"Williams","year":"2003","journal-title":"Drug Discov. Today"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/31\/4\/612\/49011482\/bioinformatics_31_4_612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/31\/4\/612\/49011482\/bioinformatics_31_4_612.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T18:41:10Z","timestamp":1675276870000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/31\/4\/612\/2748228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,17]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,2,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btu688","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,17]]}}}