{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:25:33Z","timestamp":1776284733020,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":676,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Linking genes and functional information to genetic variants identified by association studies remains difficult. Resources containing extensive genomic annotations are available but often not fully utilized due to heterogeneous data formats. To enhance their accessibility, we integrated many annotation datasets into a user-friendly webserver.<\/jats:p>\n               <jats:p>Availability and implementation: \u00a0http:\/\/www.snipa.org\/<\/jats:p>\n               <jats:p>Contact: \u00a0g.kastenmueller@helmholtz-muenchen.de<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu779","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T15:35:07Z","timestamp":1417188907000},"page":"1334-1336","source":"Crossref","is-referenced-by-count":295,"title":["<i>SNiPA<\/i>: an interactive, genetic variant-centered annotation browser"],"prefix":"10.1093","volume":"31","author":[{"given":"Matthias","family":"Arnold","sequence":"first","affiliation":[{"name":"1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, 85764 Neuherberg, Germany and 2Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, Qatar"}]},{"given":"Johannes","family":"Raffler","sequence":"additional","affiliation":[{"name":"1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, 85764 Neuherberg, Germany and 2Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, Qatar"}]},{"given":"Arne","family":"Pfeufer","sequence":"additional","affiliation":[{"name":"1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, 85764 Neuherberg, Germany and 2Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, Qatar"}]},{"given":"Karsten","family":"Suhre","sequence":"additional","affiliation":[{"name":"1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, 85764 Neuherberg, Germany and 2Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, Qatar"},{"name":"1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, 85764 Neuherberg, Germany and 2Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, Qatar"}]},{"given":"Gabi","family":"Kastenm\u00fcller","sequence":"additional","affiliation":[{"name":"1 Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health, Ingolst\u00e4dter Landstra\u00dfe 1, 85764 Neuherberg, Germany and 2Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, Qatar"}]}],"member":"286","published-online":{"date-parts":[[2014,11,26]]},"reference":[{"key":"2023051309030883900_btu779-B1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"1000 Genomes Project Consortium et al","year":"2012","journal-title":"Nature"},{"key":"2023051309030883900_btu779-B2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat. Methods"},{"key":"2023051309030883900_btu779-B3","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ejhg.2013.274","article-title":"GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies","volume":"22","author":"Beck","year":"2014","journal-title":"Eur. J. Hum Genet."},{"key":"2023051309030883900_btu779-B4","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res."},{"key":"2023051309030883900_btu779-B5","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.1142358","article-title":"Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels","volume":"316","author":"Diabetes Genetics Initiative of Broad Institute of Harvard, M.I.T., Lund University, and Novartis Institutes of BioMedical Research et al","year":"2007","journal-title":"Science"},{"key":"2023051309030883900_btu779-B6","doi-asserted-by":"crossref","first-page":"R44","DOI":"10.1186\/gb-2005-6-5-r44","article-title":"The Sequence Ontology: a tool for the unification of genome annotations","volume":"6","author":"Eilbeck","year":"2005","journal-title":"Genome Biol."},{"key":"2023051309030883900_btu779-B7","doi-asserted-by":"crossref","first-page":"D749","DOI":"10.1093\/nar\/gkt1196","article-title":"Ensembl 2014","volume":"42","author":"Flicek","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2023051309030883900_btu779-B8","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","author":"GTEx Consortium","year":"2013","journal-title":"Nat. Genet."},{"key":"2023051309030883900_btu779-B9","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1073\/pnas.0903103106","article-title":"Potential etiologic and functional implications of genome-wide association loci for human diseases and traits","volume":"106","author":"Hindorff","year":"2009","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2023051309030883900_btu779-B10","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nprot.2009.86","article-title":"Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm","volume":"4","author":"Kumar","year":"2009","journal-title":"Nat. Protoc."},{"key":"2023051309030883900_btu779-B11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature13127","article-title":"Guidelines for investigating causality of sequence variants in human disease","volume":"508","author":"MacArthur","year":"2014","journal-title":"Nature"},{"key":"2023051309030883900_btu779-B12","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1093\/bioinformatics\/btq330","article-title":"Deriving the consequences of genomic variants with the Ensembl API and SNP Effect Predictor","volume":"26","author":"McLaren","year":"2010","journal-title":"Bioinformatics"},{"key":"2023051309030883900_btu779-B13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/bioinformatics\/btr678","article-title":"seeQTL: a searchable database for human eQTLs","volume":"28","author":"Xia","year":"2012","journal-title":"Bioinformatics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/31\/8\/1334\/50306207\/bioinformatics_31_8_1334.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/31\/8\/1334\/50306207\/bioinformatics_31_8_1334.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T09:05:16Z","timestamp":1683968716000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/31\/8\/1334\/212127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,26]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btu779","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2015,4,15]]},"published":{"date-parts":[[2014,11,26]]}}}