{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:01:21Z","timestamp":1770969681255,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rationale: The growing recognition of the importance of splicing, together with rapidly accumulating RNA-sequencing data, demand robust high-throughput approaches, which efficiently analyze experimentally derived whole-transcriptome splice profiles.<\/jats:p><jats:p>Results: We have developed a computational approach, called SNPlice, for identifying cis-acting, splice-modulating variants from RNA-seq datasets. SNPlice mines RNA-seq datasets to find reads that span single-nucleotide variant (SNV) loci and nearby splice junctions, assessing the co-occurrence of variants and molecules that remain unspliced at nearby exon\u2013intron boundaries. Hence, SNPlice highlights variants preferentially occurring on intron-containing molecules, possibly resulting from altered splicing. To illustrate co-occurrence of variant nucleotide and exon\u2013intron boundary, allele-specific sequencing was used. SNPlice results are generally consistent with splice-prediction tools, but also indicate splice-modulating elements missed by other algorithms. SNPlice can be applied to identify variants that correlate with unexpected splicing events, and to measure the splice-modulating potential of canonical splice-site SNVs.<\/jats:p><jats:p>Availability and implementation: SNPlice is freely available for download from https:\/\/code.google.com\/p\/snplice\/ as a self-contained binary package for 64-bit Linux computers and as python source-code.<\/jats:p><jats:p>Contact: pmudvari@gwu.edu or horvatha@gwu.edu<\/jats:p><jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu804","type":"journal-article","created":{"date-parts":[[2014,12,7]],"date-time":"2014-12-07T01:08:27Z","timestamp":1417914507000},"page":"1191-1198","source":"Crossref","is-referenced-by-count":17,"title":["SNPlice: variants that modulate Intron retention from RNA-sequencing data"],"prefix":"10.1093","volume":"31","author":[{"given":"Prakriti","family":"Mudvari","sequence":"first","affiliation":[{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"},{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedeh","family":"Movassagh","sequence":"additional","affiliation":[{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"},{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Kowsari","sequence":"additional","affiliation":[{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"},{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Seyfi","sequence":"additional","affiliation":[{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"},{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kokkinaki","sequence":"additional","affiliation":[{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan J.","family":"Edwards","sequence":"additional","affiliation":[{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nady","family":"Golestaneh","sequence":"additional","affiliation":[{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"},{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"},{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anelia","family":"Horvath","sequence":"additional","affiliation":[{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"},{"name":"1 McCormick Genomics and Proteomics Center, 2Department of Biochemistry and Molecular Medicine and 3Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA and 4Department of Ophthalmology, 5Department of Neurology and 6Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, School of Medicine, Washington, DC 20057, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,12,6]]},"reference":[{"key":"2023051309025104200_btu804-B1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature09000","article-title":"Deciphering the splicing code","volume":"465","author":"Barash","year":"2010","journal-title":"Nature"},{"key":"2023051309025104200_btu804-B2","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1126\/science.1230612","article-title":"The evolutionary landscape of alternative splicing in vertebrate species","volume":"338","author":"Barbosa-Morais","year":"2012","journal-title":"Science"},{"key":"2023051309025104200_btu804-B3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Statist. Soc. B"},{"key":"2023051309025104200_btu804-B4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Bernstein","year":"2012","journal-title":"Nature"},{"key":"2023051309025104200_btu804-B5","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.cell.2013.02.034","article-title":"Dynamic integration of splicing within gene regulatory pathways","volume":"152","author":"Braunschweig","year":"2013","journal-title":"Cell"},{"key":"2023051309025104200_btu804-B6","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1093\/nar\/26.20.4748","article-title":"Prediction of locally optimal splice sites in plant pre-mRNA with applications to gene identification in Arabidopsis thaliana genomic DNA","volume":"26","author":"Brendel","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"2023051309025104200_btu804-B7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0022-2836(91)90380-O","article-title":"Prediction of human mRNA donor and acceptor sites from the DNA sequence","volume":"220","author":"Brunak","year":"1991","journal-title":"J. Mol. Biol."},{"key":"2023051309025104200_btu804-B8","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/emboj\/21.4.845","article-title":"SR proteins and hnRNP H regulate the splicing of the HIV-1 tev-specific exon 6D","volume":"21","author":"Caputi","year":"2002","journal-title":"EMBO J."},{"key":"2023051309025104200_btu804-B9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1017\/S1355838299981967","article-title":"The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers","volume":"5","author":"Cavaloc","year":"1999","journal-title":"RNA"},{"key":"2023051309025104200_btu804-B10","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/nature04244","article-title":"Mapping determinants of human gene expression by regional and genome-wide association","volume":"437","author":"Cheung","year":"2005","journal-title":"Nature"},{"key":"2023051309025104200_btu804-B11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/hmg\/11.4.451","article-title":"Categorization and characterization of transcript-confirmed constitutively and alternatively spliced introns and exons from human","volume":"11","author":"Clark","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"2023051309025104200_btu804-B12","doi-asserted-by":"crossref","first-page":"e1000766","DOI":"10.1371\/journal.pgen.1000766","article-title":"Fine-scale variation and genetic determinants of alternative splicing across individuals","volume":"5","author":"Coulombe-Huntington","year":"2009","journal-title":"PLoS Genet."},{"key":"2023051309025104200_btu804-B13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/wrna.1140","article-title":"Exon and intron definition in pre-mRNA splicing","volume":"4","author":"De Conti","year":"2013","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"2023051309025104200_btu804-B14","doi-asserted-by":"crossref","first-page":"W285","DOI":"10.1093\/nar\/gkm407","article-title":"SplicePort\u2013an interactive splice-site analysis tool","volume":"35","author":"Dogan","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2023051309025104200_btu804-B15","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/humu.20377","article-title":"SNPSplicer: systematic analysis of SNP-dependent splicing in genotyped cDNAs","volume":"27","author":"ElSharawy","year":"2006","journal-title":"Hum. Mutat."},{"key":"2023051309025104200_btu804-B16","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/humu.20906","article-title":"Systematic evaluation of the effect of common SNPs on pre-mRNA splicing","volume":"30","author":"ElSharawy","year":"2009","journal-title":"Hum. Mutat."},{"key":"2023051309025104200_btu804-B17","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1471-2105-12-S4-S2","article-title":"Genome-wide prediction of splice-modifying SNPs in human genes using a new analysis pipeline called AASsites","volume":"12","author":"Faber","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"2023051309025104200_btu804-B18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/biomet\/54.1-2.181","article-title":"On the bias of various estimators of the logit and its variance with application to quantal bioassay","volume":"54","author":"Gart","year":"1967","journal-title":"Biometrika"},{"key":"2023051309025104200_btu804-B19","doi-asserted-by":"crossref","first-page":"D125","DOI":"10.1093\/nar\/gks997","article-title":"SpliceAid-F: a database of human splicing factors and their RNA-binding sites","volume":"41","author":"Giulietti","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2023051309025104200_btu804-B20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1469-1809.1955.tb01285.x","article-title":"The estimation and significance of the logarithm of a ratio frequencies","volume":"20","author":"Haldane","year":"1955","journal-title":"Ann. Hum. Genet."},{"key":"2023051309025104200_btu804-B21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature12270","article-title":"MBNL proteins repress ES-cell-specific alternative splicing and reprogramming","volume":"498","author":"Han","year":"2013","journal-title":"Nature"},{"key":"2023051309025104200_btu804-B22","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1371\/journal.pgen.0030099","article-title":"Identification of common genetic variation that modulates alternative splicing","volume":"3","author":"Hull","year":"2007","journal-title":"PLoS Genet."},{"key":"2023051309025104200_btu804-B23","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1017\/S1355838202021088","article-title":"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis","volume":"8","author":"Jurica","year":"2002","journal-title":"Rna"},{"key":"2023051309025104200_btu804-B24","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1109\/TCBB.2012.53","article-title":"An evolutionary algorithm approach for feature generation from sequence data and its application to DNA splice site prediction","volume":"9","author":"Kamath","year":"2012","journal-title":"IEEE\/ACM Trans. Comput. Biol. Bioinform."},{"key":"2023051309025104200_btu804-B25","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"2023051309025104200_btu804-B26","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2023051309025104200_btu804-B27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cardiores.2005.06.024","article-title":"Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles","volume":"68","author":"Liao","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"2023051309025104200_btu804-B28","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1167\/iovs.05-1622","article-title":"Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue","volume":"47","author":"Maminishkis","year":"2006","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"2023051309025104200_btu804-B29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.gde.2011.04.001","article-title":"RNA structure and the mechanisms of alternative splicing","volume":"21","author":"McManus","year":"2011","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2023051309025104200_btu804-B30","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1126\/science.1228186","article-title":"Evolutionary dynamics of gene and isoform regulation in Mammalian tissues","volume":"338","author":"Merkin","year":"2012","journal-title":"Science"},{"key":"2023051309025104200_btu804-B31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1261\/rna.868008","article-title":"Global analysis of mRNA splicing","volume":"14","author":"Moore","year":"2008","journal-title":"RNA"},{"key":"2023051309025104200_btu804-B32","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.259","volume":"40","author":"Pan","year":"2008","journal-title":"Nat. Genet."},{"key":"2023051309025104200_btu804-B33","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1198\/106186002760180590","article-title":"An estimate of the Odds Ratio that always exists","volume":"11","author":"Parzen","year":"2002","journal-title":"J. Comput. Graphical Stat."},{"key":"2023051309025104200_btu804-B34","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/nar\/29.5.1185","article-title":"GeneSplicer: a new computational method for splice site prediction","volume":"29","author":"Pertea","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"2023051309025104200_btu804-B35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/humu.21609","article-title":"SpliceAid 2: a database of human splicing factors expression data and RNA target motifs","volume":"33","author":"Piva","year":"2012","journal-title":"Hum. Mutat."},{"key":"2023051309025104200_btu804-B36","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nbt.1550","article-title":"Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins","volume":"27","author":"Ray","year":"2009","journal-title":"Nat. Biotechnol"},{"key":"2023051309025104200_btu804-B37","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1186\/1471-2164-13-S4-S7","article-title":"Large-scale computational identification of regulatory SNPs with rSNP-MAPPER","volume":"13","author":"Riva","year":"2012","journal-title":"BMC Genomics"},{"key":"2023051309025104200_btu804-B38","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.molmed.2012.06.006","article-title":"Pre-mRNA splicing in disease and therapeutics","volume":"18","author":"Singh","year":"2012","journal-title":"Trends Mol. Med."},{"key":"2023051309025104200_btu804-B39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/gb4150","article-title":"Exon identity crisis: disease-causing mutations that disrupt the splicing code","volume":"15","author":"Sterne-Weiler","year":"2014","journal-title":"Genome Biol."},{"key":"2023051309025104200_btu804-B40","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration","volume":"14","author":"Thorvaldsd\u00f3ttir","year":"2013","journal-title":"Brief Bioinform."},{"key":"2023051309025104200_btu804-B41","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"2023051309025104200_btu804-B45","article-title":"Validation of predicted mRNA splicing mutations using high-throughput transcriptome data","author":"Viner","year":"2014"},{"key":"2023051309025104200_btu804-B42","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1261\/rna.876308","article-title":"Splicing regulation: from a parts list of regulatory elements to an integrated splicing code","volume":"14","author":"Wang","year":"2008","journal-title":"RNA"},{"key":"2023051309025104200_btu804-B43","doi-asserted-by":"crossref","first-page":"R20","DOI":"10.1186\/gb-2010-11-2-r20","article-title":"Genomic features defining exonic variants that modulate splicing","volume":"11","author":"Woolfe","year":"2010","journal-title":"Genome Biol."},{"key":"2023051309025104200_btu804-B44","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/1066527041410418","article-title":"Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals","volume":"11","author":"Yeo","year":"2004","journal-title":"J. Comput. Biol."}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/31\/8\/1191\/50306244\/bioinformatics_31_8_1191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/31\/8\/1191\/50306244\/bioinformatics_31_8_1191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T17:42:31Z","timestamp":1717609351000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/31\/8\/1191\/212637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,6]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btu804","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2015,4,15]]},"published":{"date-parts":[[2014,12,6]]}}}