{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:35:35Z","timestamp":1777660535981,"version":"3.51.4"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Circular permutation is an important type of protein rearrangement. Natural circular permutations have implications for protein function, stability and evolution. Artificial circular permutations have also been used for protein studies. However, such relationships are difficult to detect for many sequence and structure comparison algorithms and require special consideration.<\/jats:p>\n               <jats:p>Results: We developed a new algorithm, called Combinatorial Extension for Circular Permutations (CE-CP), which allows the structural comparison of circularly permuted proteins. CE-CP was designed to be user friendly and is integrated into the RCSB Protein Data Bank. It was tested on two collections of circularly permuted proteins. Pairwise alignments can be visualized both in a desktop application or on the web using Jmol and exported to other programs in a variety of formats.<\/jats:p>\n               <jats:p>Availability and implementation: The CE-CP algorithm can be accessed through the RCSB website at http:\/\/www.rcsb.org\/pdb\/workbench\/workbench.do. Source code is available under the LGPL 2.1 as part of BioJava 3 (http:\/\/biojava.org; http:\/\/github.com\/biojava\/biojava).<\/jats:p>\n               <jats:p>Contact: \u00a0sbliven@ucsd.edu or info@rcsb.org.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu823","type":"journal-article","created":{"date-parts":[[2014,12,14]],"date-time":"2014-12-14T01:33:54Z","timestamp":1418520834000},"page":"1316-1318","source":"Crossref","is-referenced-by-count":21,"title":["Detection of circular permutations within protein structures using CE-CP"],"prefix":"10.1093","volume":"31","author":[{"given":"Spencer E.","family":"Bliven","sequence":"first","affiliation":[{"name":"1 Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA 92093, USA, 2National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA and 3RCSB Protein Data Bank, San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, USA"},{"name":"1 Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA 92093, USA, 2National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA and 3RCSB Protein Data Bank, San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip E.","family":"Bourne","sequence":"additional","affiliation":[{"name":"1 Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA 92093, USA, 2National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA and 3RCSB Protein Data Bank, San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, USA"},{"name":"1 Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA 92093, USA, 2National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA and 3RCSB Protein Data Bank, San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Prli\u0107","sequence":"additional","affiliation":[{"name":"1 Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA 92093, USA, 2National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA and 3RCSB Protein Data Bank, San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,12,12]]},"reference":[{"key":"2023051309021633300_btu823-B1","doi-asserted-by":"crossref","first-page":"e1002445","DOI":"10.1371\/journal.pcbi.1002445","article-title":"Circular permutation in proteins","volume":"8","author":"Bliven","year":"2012","journal-title":"PLoS Comput. 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