{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:55:56Z","timestamp":1768982156594,"version":"3.49.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":660,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The field of toxicogenomics (the application of \u2018-omics\u2019 technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available.<\/jats:p>\n               <jats:p>Results: The Data Infrastructure for Chemical Safety Assessment (diXa) is a robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal.<\/jats:p>\n               <jats:p>Availability and implementation: \u00a0http:\/\/www.dixa-fp7.eu<\/jats:p>\n               <jats:p>Contact: \u00a0d.hendrickx@maastrichtuniversity.nl; info@dixa-fp7.eu<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btu827","type":"journal-article","created":{"date-parts":[[2014,12,14]],"date-time":"2014-12-14T01:33:54Z","timestamp":1418520834000},"page":"1505-1507","source":"Crossref","is-referenced-by-count":29,"title":["diXa: a data infrastructure for chemical safety assessment"],"prefix":"10.1093","volume":"31","author":[{"given":"Diana M.","family":"Hendrickx","sequence":"first","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Hugo J.W.L.","family":"Aerts","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Florian","family":"Caiment","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Dominic","family":"Clark","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Timothy M.D.","family":"Ebbels","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Chris T.","family":"Evelo","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Hans","family":"Gmuender","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The 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London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"J\u00fcrgen","family":"Hescheler","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Danyel G.J.","family":"Jennen","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome 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Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Stathis","family":"Kanterakis","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, 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2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Vera","family":"Matser","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"John P.","family":"Overington","sequence":"additional","affiliation":[{"name":"1 Department of 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Italy"}]},{"given":"Ekaterina","family":"Pilicheva","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Ugis","family":"Sarkans","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Marcelo P.","family":"Segura-Lepe","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD Maastricht, The Netherlands, 6Genedata AG, CH-4053 Basel, Switzerland, 7Department of Vertebrate Genomics, Max Planck Institute for Molecular 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7Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany, 8Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany and 9European Commission, Joint Research Centre, 21027 Ispra VA, Italy"}]},{"given":"Timo","family":"Wittenberger","sequence":"additional","affiliation":[{"name":"1 Department of Toxicogenomics, School of Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands, 2Dana-Farber Cancer Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, 02215, MA, USA, 3European Molecular Biology Laboratory \u2013 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SD, UK, 4Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK, 5Department of Bioinformatics \u2013 BiGCaT, Maastricht University, 6200 MD 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