{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:01:47Z","timestamp":1777554107363,"version":"3.51.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: miR2GO is a web-based platform for comparative analyses of human miRNA functions. It includes two programs: miRmut2GO and miRpair2GO. miRmut2GO implements a knowledge-based method to assess the functional effects of genetic and somatic mutations in microRNA seed regions. The functional effects of a mutation are analysed by semantic comparison of enriched gene ontology (GO) annotations of the target gene sets for the wild-type and mutated alleles. miRpair2GO compares the functions of two different miRNAs based on the enriched functional annotations of their target gene sets.<\/jats:p>\n               <jats:p>Availability and implementation: The miR2GO web server is available at http:\/\/compbio.uthsc.edu\/miR2GO.<\/jats:p>\n               <jats:p>Contact: \u00a0ycui2@uthsc.edu<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv140","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:32:06Z","timestamp":1426120326000},"page":"2403-2405","source":"Crossref","is-referenced-by-count":30,"title":["miR2GO: comparative functional analysis for microRNAs"],"prefix":"10.1093","volume":"31","author":[{"given":"Anindya","family":"Bhattacharya","sequence":"first","affiliation":[{"name":"1 Department of Microbiology, Immunology and Biochemistry and"},{"name":"2 Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[{"name":"1 Department of Microbiology, Immunology and Biochemistry and"},{"name":"2 Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"2023020202155393300_btv140-B1","doi-asserted-by":"crossref","first-page":"D51","DOI":"10.1093\/nar\/gkl797","article-title":"PolymiRTS database: linking polymorphisms in microRNA target sites with complex traits","volume":"35","author":"Bao","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"2023020202155393300_btv140-B2","doi-asserted-by":"crossref","first-page":"D977","DOI":"10.1093\/nar\/gks1138","article-title":"SomamiR: a database for somatic mutations impacting microRNA function in cancer","volume":"41","author":"Bhattacharya","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"2023020202155393300_btv140-B3","doi-asserted-by":"crossref","first-page":"D86","DOI":"10.1093\/nar\/gkt1028","article-title":"PolymiRTS database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways","volume":"42","author":"Bhattacharya","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2023020202155393300_btv140-B4","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1186\/gb-2003-5-1-r1","article-title":"MicroRNA targets in Drosophila","volume":"5","author":"Enright","year":"2003","journal-title":"Genome Biol."},{"key":"2023020202155393300_btv140-B5","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbu044","article-title":"Comprehensive overview and assessment of computational prediction of microRNA targets in animals","author":"Fan","year":"2015","journal-title":"Briefings Bioinform"},{"key":"2023020202155393300_btv140-B6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"2023020202155393300_btv140-B7","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/1097-024X(200009)30:11<1203::AID-SPE338>3.0.CO;2-N","article-title":"An open graph visualization system and its applications to software engineering","volume":"30","author":"Gansner","year":"2000","journal-title":"Softw. 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