{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:55:13Z","timestamp":1790697313117,"version":"4.1.0"},"reference-count":165,"publisher":"Oxford University Press (OUP)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Long non-coding RNAs (lncRNAs) form the largest class of non-protein coding genes in the human genome. While a small subset of well-characterized lncRNAs has demonstrated their significant role in diverse biological functions like chromatin modifications, post-transcriptional regulation, imprinting etc., the functional significance of a vast majority of them still remains an enigma. Increasing evidence of the implications of lncRNAs in various diseases including cancer and major developmental processes has further enhanced the need to gain mechanistic insights into the lncRNA functions. Here, we present a comprehensive review of the various computational approaches and tools available for the identification and annotation of long non-coding RNAs. We also discuss a conceptual roadmap to systematically explore the functional properties of the lncRNAs using computational approaches.<\/jats:p>\n               <jats:p>Contact: vinods@igib.in<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv148","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:26:10Z","timestamp":1426551970000},"page":"2241-2251","source":"Crossref","is-referenced-by-count":52,"title":["Computational approaches towards understanding human long non-coding RNA biology"],"prefix":"10.1093","volume":"31","author":[{"given":"Saakshi","family":"Jalali","sequence":"first","affiliation":[{"name":"1 GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110020, India and"},{"name":"1 GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110020, India and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Kapoor","sequence":"additional","affiliation":[{"name":"1 GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110020, India and"},{"name":"1 GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110020, India and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambily","family":"Sivadas","sequence":"additional","affiliation":[{"name":"1 GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110020, India and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeksha","family":"Bhartiya","sequence":"additional","affiliation":[{"name":"1 GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110020, India and"},{"name":"1 GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110020, India and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Scaria","sequence":"additional","affiliation":[{"name":"1 GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110020, India and"},{"name":"1 GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB), Mathura Road, Delhi 110020, India and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,15]]},"reference":[{"key":"2023020202153949300_btv148-B1","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1093\/bioinformatics\/btt495","article-title":"catRAPID omics: a web server for large-scale prediction of protein-RNA interactions","volume":"29","author":"Agostini","year":"2013","journal-title":"Bioinformatics"},{"key":"2023020202153949300_btv148-B2","doi-asserted-by":"crossref","first-page":"D146","DOI":"10.1093\/nar\/gkq1138","article-title":"lncRNAdb: a reference database for long noncoding RNAs","volume":"39","author":"Amaral","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"2023020202153949300_btv148-B3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrg3520","article-title":"Emerging evidence for functional peptides encoded by short open reading frames","volume":"15","author":"Andrews","year":"2014","journal-title":"Nat. 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