{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:35:23Z","timestamp":1773286523487,"version":"3.50.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Many important problems in cell biology require dense non-linear interactions between functional modules to be considered. The importance of computer simulation in understanding cellular processes is now widely accepted, and a variety of simulation algorithms useful for studying certain subsystems have been designed. Expansion of hematopoietic stem and progenitor cells (HSC\/HPC) in ex vivo culture with cytokines and small molecules is a method to increase the restricted numbers of stem cells found in umbilical cord blood (CB), while also enhancing the content of early engrafting neutrophil and platelet precursors. The efficacy of the expanded product depends on the composition of the cocktail of cytokines and small molecules used for culture. Testing the influence of a cytokine or small molecule on the expansion of HSC\/HPC is a laborious and expensive process. We therefore developed a computational model based on cellular signaling interactions that predict the influence of a cytokine on the survival, duplication and differentiation of the CD133+ HSC\/HPC subset from human umbilical CB.<\/jats:p>\n               <jats:p>Results: We have used results from in\u00a0vitro expansion cultures with different combinations of one or more cytokines to develop an ordinary differential equation model that includes the effect of cytokines on survival, duplication and differentiation of the CD133+ HSC\/HPC. Comparing the results of in\u00a0vitro and in silico experiments, we show that the model can predict the effect of a cytokine on the fold expansion and differentiation of CB CD133+ HSC\/HPC after 8-day culture on a 3D scaffold.<\/jats:p>\n               <jats:p>Availability and implementation: The model is available visiting the following URL: http:\/\/www.francescopappalardo.net\/Bioinformatics_CD133_Model.<\/jats:p>\n               <jats:p>Contact: \u00a0francesco.pappalardo@unict.it or suzanne.watt@nhsbt.nhs.uk<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv172","type":"journal-article","created":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T04:39:55Z","timestamp":1427344795000},"page":"2514-2522","source":"Crossref","is-referenced-by-count":30,"title":["Computational modeling of the expansion of human cord blood CD133+ hematopoietic stem\/progenitor cells with different cytokine combinations"],"prefix":"10.1093","volume":"31","author":[{"given":"Francesca","family":"Gullo","sequence":"first","affiliation":[{"name":"1 Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK,"},{"name":"2 NHS Blood and Transplant Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"van der Garde","sequence":"additional","affiliation":[{"name":"1 Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK,"},{"name":"2 NHS Blood and Transplant Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Russo","sequence":"additional","affiliation":[{"name":"3 Department of Drug Science and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzio","family":"Pennisi","sequence":"additional","affiliation":[{"name":"4 Department of Mathematics and Computer Science, University of Catania, 95125 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santo","family":"Motta","sequence":"additional","affiliation":[{"name":"4 Department of Mathematics and Computer Science, University of Catania, 95125 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Pappalardo","sequence":"additional","affiliation":[{"name":"3 Department of Drug Science and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Watt","sequence":"additional","affiliation":[{"name":"1 Stem Cell Research, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK,"},{"name":"2 NHS Blood and Transplant Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"2023051308490367500_btv172-B1","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1182\/blood-2010-08-300491","article-title":"Influence of infused cell dose and HLA match on engraftment after double-unit cord blood allografts","volume":"117","author":"Avery","year":"2011","journal-title":"Blood"},{"key":"2023051308490367500_btv172-B2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1182\/blood-2013-02-453175","article-title":"Umbilical cord blood transplantation: the first 25 years and beyond","volume":"122","author":"Ballen","year":"2013","journal-title":"Blood"},{"key":"2023051308490367500_btv172-B3","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1182\/blood-2013-07-505099","article-title":"Notch signals are required for in\u00a0vitro but not in\u00a0vivo maintenance of human hematopoietic stem cells and delay the appearance of multipotent progenitors","volume":"123","author":"Benveniste","year":"2014","journal-title":"Blood"},{"key":"2023051308490367500_btv172-B4","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.1191536","article-title":"Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells","volume":"329","author":"Boitano","year":"2010","journal-title":"Science"},{"key":"2023051308490367500_btv172-B5","first-page":"3688","article-title":"Critical impact of the kinetics of dendritic cells activation on the in\u00a0vivo induction of tumor-specific T lymphocytes","volume":"63","author":"Camporeale","year":"2003","journal-title":"Cancer Res."},{"key":"2023051308490367500_btv172-B6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1051\/mmnp\/20127304","article-title":"A modeling framework for immune-related diseases","volume":"7","author":"Castiglione","year":"2012","journal-title":"Math. 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Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal","volume":"345","author":"Fares","year":"2014","journal-title":"Science"},{"key":"2023051308490367500_btv172-B22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature13498","article-title":"The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function","volume":"514","author":"Fonseca-Pereira","year":"2014","journal-title":"Nature"},{"key":"2023051308490367500_btv172-B23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/CCO.0b013e32835d815f","article-title":"Alternative transplant donor sources: is there any consensus? Curr","volume":"25","author":"Fuchs","year":"2013","journal-title":"Opin. 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Biology and potential clinical application","volume":"9","author":"Shurin","year":"1998","journal-title":"Cytokine Growth Factor Rev."},{"key":"2023051308490367500_btv172-B50","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/leu.2013.326","article-title":"CD133 is a positive marker for a distinct class of primitive human cord blood-derived CD34-negative hematopoietic stem cells","volume":"28","author":"Takahashi","year":"2014","journal-title":"Leukemia"},{"key":"2023051308490367500_btv172-B51","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.cytogfr.2011.09.001","article-title":"Principal signalling complexes in haematopoiesis: structural aspects and mimetic discovery","volume":"22","author":"Tarasova","year":"2011","journal-title":"Cytokine Growth Factor Rev."},{"key":"2023051308490367500_btv172-B52","article-title":"Thrombopoietin treatment of one graft in a double cord blood transplant provides early platelet recovery while contributing to long-term engraftment in NSG mice","author":"van der Garde","year":"2014","journal-title":"Stem Cells Dev."},{"key":"2023051308490367500_btv172-B53","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1182\/blood-2002-01-0294","article-title":"Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival","volume":"100","author":"Wagner","year":"2002","journal-title":"Blood"},{"key":"2023051308490367500_btv172-B54","article-title":"Umbilical cord blood banking","volume-title":"Reference Module in Biomedical Sciences","author":"Watt","year":"2014"},{"key":"2023051308490367500_btv172-B55","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/mt.2013.40","article-title":"CD34(+) expansion with Delta-1 and HOXB4 promotes rapid engraftment and transfusion independence in a Macaca nemestrina cord blood transplant model","volume":"21","author":"Watts","year":"2013","journal-title":"Mol. 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