{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:23:57Z","timestamp":1766157837672},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":542,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: The Cellular Phenotype Database (CPD) is a repository for data derived from high-throughput systems microscopy studies. The aims of this resource are: (i) to provide easy access to cellular phenotype and molecular localization data for the broader research community; (ii) to facilitate integration of independent phenotypic studies by means of data aggregation techniques, including use of an ontology and (iii) to facilitate development of analytical methods in this field.<\/jats:p>\n               <jats:p>Results: In this article we present CPD, its data structure and user interface, propose a minimal set of information describing RNA interference experiments, and suggest a generic schema for management and aggregation of outputs from phenotypic or molecular localization experiments. The database has a flexible structure for management of data from heterogeneous sources of systems microscopy experimental outputs generated by a variety of protocols and technologies and can be queried by gene, reagent, gene attribute, study keywords, phenotype or ontology terms.<\/jats:p>\n               <jats:p>Availability and implementation: CPD is developed as part of the Systems Microscopy Network of Excellence and is accessible at http:\/\/www.ebi.ac.uk\/fg\/sym.<\/jats:p>\n               <jats:p>Contact: \u00a0jes@ebi.ac.uk or ugis@ebi.ac.uk<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv199","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T03:32:53Z","timestamp":1428723173000},"page":"2736-2740","source":"Crossref","is-referenced-by-count":11,"title":["Cellular phenotype database: a repository for systems microscopy data"],"prefix":"10.1093","volume":"31","author":[{"given":"Catherine","family":"Kirsanova","sequence":"first","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvis","family":"Brazma","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Rustici","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugis","family":"Sarkans","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton CB10 1SD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"2023020202212820500_btv199-B1","doi-asserted-by":"crossref","first-page":"e52337","DOI":"10.1371\/journal.pone.0052337","article-title":"Automated analysis of NF-\u03baB nuclear translocation kinetics in high-throughput screening","volume":"7","author":"Di","year":"2012","journal-title":"PLoS One"},{"key":"2023020202212820500_btv199-B2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/msb.2010.25","article-title":"Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Clustering phenotype populations by genome-wide RNAi and multiparametric imaging","volume":"6","author":"Fuchs","year":"2010","journal-title":"Mol. Syst. Biol."},{"key":"2023020202212820500_btv199-B3","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.cell.2012.06.039","article-title":"TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes","volume":"150","author":"Gudjonsson","year":"2012","journal-title":"Cell"},{"key":"2023020202212820500_btv199-B4","doi-asserted-by":"crossref","DOI":"10.1186\/1752-0509-5-65","article-title":"A protein network-guided screen for cell cycle regulators in Drosophila","volume":"5","author":"Guest","year":"2011","journal-title":"BMC Syst. 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