{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T04:10:19Z","timestamp":1675311019755},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: We describe the implementation of the method introduced by Chambaz et\u00a0al. in 2012. We also demonstrate its genome-wide application to the integrative search of new regions with strong association between DNA copy number and gene expression accounting for DNA methylation in breast cancers.<\/jats:p>\n               <jats:p>Availability and implementation: An open-source R package tmle.npvi is available from CRAN (http:\/\/cran.r-project.org\/).<\/jats:p>\n               <jats:p>Contact: \u00a0pierre.neuvial@genopole.cnrs.fr<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv320","type":"journal-article","created":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T00:50:24Z","timestamp":1432342224000},"page":"3054-3056","source":"Crossref","is-referenced-by-count":3,"title":["tmle.npvi: targeted, integrative search of associations between DNA copy number and gene expression, accounting for DNA methylation"],"prefix":"10.1093","volume":"31","author":[{"given":"Antoine","family":"Chambaz","sequence":"first","affiliation":[{"name":"1 Modal\u2019X, Universit\u00e9 Paris Ouest Nanterre, Nanterre, France and 2Laboratoire de Math\u00e9matiques et Mod\u00e9lisation d\u2019\u00c9vry, Universit\u00e9 d\u2019\u00c9vry val d\u2019Essonne, UMR CNRS 8071, ENSIIE, USC INRA, \u00c9vry, France"}]},{"given":"Pierre","family":"Neuvial","sequence":"additional","affiliation":[{"name":"1 Modal\u2019X, Universit\u00e9 Paris Ouest Nanterre, Nanterre, France and 2Laboratoire de Math\u00e9matiques et Mod\u00e9lisation d\u2019\u00c9vry, Universit\u00e9 d\u2019\u00c9vry val d\u2019Essonne, UMR CNRS 8071, ENSIIE, USC INRA, \u00c9vry, France"}]}],"member":"286","published-online":{"date-parts":[[2015,5,21]]},"reference":[{"key":"2023020202234976800_btv320-B1","doi-asserted-by":"crossref","first-page":"e8665","DOI":"10.1371\/journal.pone.0008665","article-title":"Multi-platform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number","volume":"5","author":"Andrews","year":"2010","journal-title":"PLoS ONE"},{"key":"2023020202234976800_btv320-B2","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1214\/12-EJS703","article-title":"Estimation of a non-parametric variable importance measure of a continuous exposure","volume":"6","author":"Chambaz","year":"2012","journal-title":"Electron. 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Biostat."},{"key":"2023020202234976800_btv320-B9","first-page":"19","article-title":"Nonparametric testing for DNA copy number induced differential mRNA gene expression","volume":"5","author":"van Wieringen","year":"2008","journal-title":"Biometrics"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/31\/18\/3054\/49035278\/bioinformatics_31_18_3054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/31\/18\/3054\/49035278\/bioinformatics_31_18_3054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T03:42:47Z","timestamp":1675309367000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/31\/18\/3054\/241218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,21]]},"references-count":9,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2015,9,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btv320","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2015,9,15]]},"published":{"date-parts":[[2015,5,21]]}}}