{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:34:40Z","timestamp":1772138080277,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2016,10,2]],"date-time":"2016-10-02T00:00:00Z","timestamp":1475366400000},"content-version":"vor","delay-in-days":450,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Summary: Mutational signatures are patterns in the occurrence of somatic single-nucleotide variants that can reflect underlying mutational processes. The SomaticSignatures package provides flexible, interoperable and easy-to-use tools that identify such signatures in cancer sequencing data. It facilitates large-scale, cross-dataset estimation of mutational signatures, implements existing methods for pattern decomposition, supports extension through user-defined approaches and integrates with existing Bioconductor workflows.<\/jats:p>\n                  <jats:p>Availability and implementation: The R package SomaticSignatures is available as part of the Bioconductor project. Its documentation provides additional details on the methods and demonstrates applications to biological datasets.<\/jats:p>\n                  <jats:p>Contact: \u00a0julian.gehring@embl.de, whuber@embl.de<\/jats:p>\n                  <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv408","type":"journal-article","created":{"date-parts":[[2015,7,11]],"date-time":"2015-07-11T20:20:01Z","timestamp":1436646001000},"page":"3673-3675","source":"Crossref","is-referenced-by-count":284,"title":["SomaticSignatures: inferring mutational signatures from single-nucleotide variants"],"prefix":"10.1093","volume":"31","author":[{"given":"Julian S.","family":"Gehring","sequence":"first","affiliation":[{"name":"1 European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany,"},{"name":"2 Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA 94080, USA and"}]},{"given":"Bernd","family":"Fischer","sequence":"additional","affiliation":[{"name":"1 European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany,"},{"name":"3 Computational Genome Biology, German Cancer Research Center, 69120 Heidelberg, Germany"}]},{"given":"Michael","family":"Lawrence","sequence":"additional","affiliation":[{"name":"2 Department of Bioinformatics and Computational Biology, Genentech Inc., South San Francisco, CA 94080, USA and"}]},{"given":"Wolfgang","family":"Huber","sequence":"additional","affiliation":[{"name":"1 European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany,"}]}],"member":"286","published-online":{"date-parts":[[2015,7,10]]},"reference":[{"key":"2023020202404554100_btv408-B1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.celrep.2012.12.008","article-title":"Deciphering signatures of mutational processes operative in human cancer","volume":"3","author":"Alexandrov","year":"2013","journal-title":"Cell Rep."},{"key":"2023020202404554100_btv408-B2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"2023020202404554100_btv408-B3","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1073\/pnas.0308531101","article-title":"Metagenes and molecular pattern discovery using matrix factorization","volume":"101","author":"Brunet","year":"2004","journal-title":"Proc. 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