{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:37:14Z","timestamp":1784129834954,"version":"3.55.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: When processing gene expression profiles or other biological data, it is often required to assign measurements to distinct categories (e.g. \u2018high\u2019 and \u2018low\u2019 and possibly \u2018intermediate\u2019). Subsequent analyses strongly depend on the results of this quantization. Poor quantization will have potentially misleading effects on further investigations. We propose the BiTrinA package that integrates different multiscale algorithms for binarization and for trinarization of one-dimensional data with methods for quality assessment and visualization of the results. By identifying measurements that show large variations over different time points or conditions, this quality assessment can determine candidates that are related to the specific experimental setting.<\/jats:p>\n               <jats:p>Availability and implementation: BiTrinA is freely available on CRAN.<\/jats:p>\n               <jats:p>Contact: \u00a0hans.kestler@leibniz-fli.de or hans.kestler@uni-ulm.de<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv591","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T01:18:17Z","timestamp":1444871897000},"page":"465-468","source":"Crossref","is-referenced-by-count":23,"title":["BiTrinA\u2014multiscale binarization and trinarization with quality analysis"],"prefix":"10.1093","volume":"32","author":[{"given":"Christoph","family":"M\u00fcssel","sequence":"first","affiliation":[{"name":"1 Medical Systems Biology, Ulm University, 89069 Ulm, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Schmid","sequence":"additional","affiliation":[{"name":"1 Medical Systems Biology, Ulm University, 89069 Ulm, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara J.","family":"Bl\u00e4tte","sequence":"additional","affiliation":[{"name":"1 Medical Systems Biology, Ulm University, 89069 Ulm, Germany,"},{"name":"2 Section of Oncology, Internal Medicine III, Ulm University, 89069 Ulm, Germany and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hopfensitz","sequence":"additional","affiliation":[{"name":"1 Medical Systems Biology, Ulm University, 89069 Ulm, Germany,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwig","family":"Lausser","sequence":"additional","affiliation":[{"name":"3 Leibniz Institute on Aging\u2014Fritz Lipmann Institute, 07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans A.","family":"Kestler","sequence":"additional","affiliation":[{"name":"1 Medical Systems Biology, Ulm University, 89069 Ulm, Germany,"},{"name":"3 Leibniz Institute on Aging\u2014Fritz Lipmann Institute, 07745 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,10,14]]},"reference":[{"key":"2023020110313193200_btv591-B1","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1126\/science.1072152","article-title":"Gene expression during the life cycle of drosophila melanogaster","volume":"297","author":"Arbeitman","year":"2002","journal-title":"Science"},{"key":"2023020110313193200_btv591-B2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00994018","article-title":"Support-vector networks","volume":"20","author":"Cortes","year":"1995","journal-title":"Mach. 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