{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:19:29Z","timestamp":1770833969651,"version":"3.50.1"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","funder":[{"DOI":"10.13039\/100000092","name":"National Library of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T15LM009451"],"award-info":[{"award-number":["T15LM009451"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20HL113445"],"award-info":[{"award-number":["P20HL113445"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Motivation: Current differential correlation methods are designed to determine molecular feature pairs that have the largest magnitude of difference between correlation coefficients. These methods do not easily capture molecular feature pairs that experience no correlation in one group but correlation in another, which may reflect certain types of biological interactions. We have developed a tool, the Discordant method, which categorizes the correlation types for each group to make this possible.<\/jats:p><jats:p>Results: We compare the Discordant method to existing approaches using simulations and two biological datasets with different types of \u2013omics data. In contrast to other methods, Discordant identifies phenotype-related features at a similar or higher rate while maintaining reasonable computational tractability and usability.<\/jats:p><jats:p>Availability and implementation: R code and sample data are available at https:\/\/github.com\/siskac\/discordant.<\/jats:p><jats:p>Contact: \u00a0katerina.kechris@ucdenver.edu<\/jats:p><jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv633","type":"journal-article","created":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:38:37Z","timestamp":1446338317000},"page":"690-696","source":"Crossref","is-referenced-by-count":31,"title":["The discordant method: a novel approach for differential correlation"],"prefix":"10.1093","volume":"32","author":[{"given":"Charlotte","family":"Siska","sequence":"first","affiliation":[{"name":"1 Computational Bioscience Program, Department of Pharmacology, University of Colorado Denver,"}]},{"given":"Russell","family":"Bowler","sequence":"additional","affiliation":[{"name":"2 Department of Medicine, National Jewish, Denver, CO and"}]},{"given":"Katerina","family":"Kechris","sequence":"additional","affiliation":[{"name":"3 Department of Biostatistics and Informatics, University of Colorado Denver, Denver, CO, USA"}]}],"member":"286","published-online":{"date-parts":[[2015,10,31]]},"reference":[{"key":"2023020110432905800_btv633-B1","doi-asserted-by":"crossref","first-page":"D504","DOI":"10.1093\/nar\/gkj126","article-title":"Pathguide: a pathway resource list","volume":"34","author":"Bader","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"2023020110432905800_btv633-B2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1165\/rcmb.2012-0230OC","article-title":"Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease","volume":"49","author":"Bahr","year":"2013","journal-title":"Am. 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