{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T10:06:51Z","timestamp":1725530811437},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Pleiotropy is common in the genetic architectures of complex diseases. To the best of our knowledge, no analysis tool has been developed for identifying pleiotropic pathways using multiple genome-wide association study (GWAS) summaries by now. Here, we present PAPA, a flexible tool for pleiotropic pathway analysis utilizing GWAS summary results. The performance of PAPA was validated using publicly available GWAS summaries of body mass index and waist-hip ratio of the GIANT datasets. PAPA identified a set of pleiotropic pathways, which have been demonstrated to be involved in the development of obesity.<\/jats:p>\n               <jats:p>Availability and implementation \u00a0: PAPA program, document and illustrative example are available at http:\/\/sourceforge.net\/projects\/papav1\/files\/.<\/jats:p>\n               <jats:p>Contact \u00a0: \u00a0fzhxjtu@mail.xjtu.edu.cn<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv668","type":"journal-article","created":{"date-parts":[[2015,11,15]],"date-time":"2015-11-15T01:38:21Z","timestamp":1447551501000},"page":"946-948","source":"Crossref","is-referenced-by-count":8,"title":["PAPA: a flexible tool for identifying pleiotropic pathways using genome-wide association study summaries"],"prefix":"10.1093","volume":"32","author":[{"given":"Yan","family":"Wen","sequence":"first","affiliation":[{"name":"Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, People\u2019s Republic of China"}]},{"given":"Wenyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, People\u2019s Republic of China"}]},{"given":"Xiong","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, People\u2019s Republic of China"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, People\u2019s Republic of China"}]}],"member":"286","published-online":{"date-parts":[[2015,11,14]]},"reference":[{"key":"2023020111565881900_btv668-B1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1534\/g3.112.002618","article-title":"Uncovering networks from genome-wide association studies via circular genomic permutation","volume":"2","author":"Cabrera","year":"2012","journal-title":"G3"},{"key":"2023020111565881900_btv668-B2","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1136\/annrheumdis-2012-202081","article-title":"Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data, Ann","volume":"72","author":"Elliott","year":"2013","journal-title":"Rheum. 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