{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:28:17Z","timestamp":1769092097173,"version":"3.49.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Purpose: The rcellminer R package provides a wide range of functionality to help R users access and explore molecular profiling and drug response data for the NCI-60. The package enables flexible programmatic access to CellMiner\u2019s unparalleled breadth of NCI-60 data, including gene and protein expression, copy number, whole exome mutations, as well as activity data for \u223c21K compounds, with information on their structure, mechanism of action and repeat screens. Functions are available to easily visualize compound structures, activity patterns and molecular feature profiles. Additionally, embedded R Shiny applications allow interactive data exploration.<\/jats:p>\n               <jats:p>Availability and implementation: rcellminer is compatible with R 3.2 and above on Windows, Mac OS X and Linux. The package, documentation, tutorials and Shiny-based applications are available through Bioconductor (http:\/\/www.bioconductor.org\/packages\/rcellminer); ongoing updates will occur according to the Bioconductor release schedule with new CellMiner data. The package is free and open-source (LGPL 3).<\/jats:p>\n               <jats:p>Contact: \u00a0lunaa@cbio.mskcc.org or vinodh.rajapakse@nih.gov<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv701","type":"journal-article","created":{"date-parts":[[2015,12,4]],"date-time":"2015-12-04T01:49:46Z","timestamp":1449193786000},"page":"1272-1274","source":"Crossref","is-referenced-by-count":40,"title":["rcellminer: exploring molecular profiles and drug response of the NCI-60 cell lines in R"],"prefix":"10.1093","volume":"32","author":[{"given":"Augustin","family":"Luna","sequence":"first","affiliation":[{"name":"1 Computer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinodh N.","family":"Rajapakse","sequence":"additional","affiliation":[{"name":"2 Developmental Therapeutic Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio G.","family":"Sousa","sequence":"additional","affiliation":[{"name":"3 Centro De Estudos Em C\u00e9lulas Tronco, Terapia Celular E Gen\u00e9tica Toxicol\u00f3gica, Programa De P\u00f3s-Gradua\u00e7\u00e3o Em Farm\u00e1cia, Universidade Federal De Mato Grosso Do Sul, Campo Grande, MS 79070-900, Brazil and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjiong","family":"Gao","sequence":"additional","affiliation":[{"name":"4 Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Schultz","sequence":"additional","affiliation":[{"name":"4 Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudhir","family":"Varma","sequence":"additional","affiliation":[{"name":"2 Developmental Therapeutic Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Reinhold","sequence":"additional","affiliation":[{"name":"2 Developmental Therapeutic Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Sander","sequence":"additional","affiliation":[{"name":"1 Computer Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Pommier","sequence":"additional","affiliation":[{"name":"2 Developmental Therapeutic Branch, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,12,3]]},"reference":[{"key":"2023020112213167000_btv701-B1","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1158\/0008-5472.CAN-12-3342","article-title":"The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology","volume":"73","author":"Abaan","year":"2013","journal-title":"Cancer Res"},{"key":"2023020112213167000_btv701-B2","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1093\/bioinformatics\/btn307","article-title":"ChemmineR: a compound mining framework for R","volume":"24","author":"Cao","year":"2008","journal-title":"Bioinformatics"},{"key":"2023020112213167000_btv701-B3","doi-asserted-by":"crossref","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. 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