{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T23:50:30Z","timestamp":1769557830908,"version":"3.49.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: RNA interference (RNAi) technology is being developed as a weapon for pest insect control. To maximize the specificity that such an approach affords we have developed a bioinformatic web tool that searches the ever-growing arthropod transcriptome databases so that pest-specific RNAi sequences can be identified. This will help technology developers finesse the design of RNAi sequences and suggests which non-target species should be assessed in the risk assessment process.<\/jats:p>\n               <jats:p>Availability and implementation: \u00a0http:\/\/rnai.specifly.org.<\/jats:p>\n               <jats:p>Contact: \u00a0crobin@unimelb.edu.au<\/jats:p>","DOI":"10.1093\/bioinformatics\/btv747","type":"journal-article","created":{"date-parts":[[2015,12,25]],"date-time":"2015-12-25T03:13:42Z","timestamp":1451013222000},"page":"1232-1234","source":"Crossref","is-referenced-by-count":22,"title":["OfftargetFinder: a web tool for species-specific RNAi design"],"prefix":"10.1093","volume":"32","author":[{"given":"R.T.","family":"Good","sequence":"first","affiliation":[{"name":"1 The Bio21 Institute"},{"name":"2 School of Biosciences, The University of Melbourne, Melbourne 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Varghese","sequence":"additional","affiliation":[{"name":"3 CSIRO National Facilities and Collections, Canberra, ACT 2601, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.F.","family":"Golz","sequence":"additional","affiliation":[{"name":"2 School of Biosciences, The University of Melbourne, Melbourne 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.A.","family":"Russell","sequence":"additional","affiliation":[{"name":"4 Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Papanicolaou","sequence":"additional","affiliation":[{"name":"5 CSIRO Land and Water Flagship, Canberra, ACT 2601, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Edwards","sequence":"additional","affiliation":[{"name":"5 CSIRO Land and Water Flagship, Canberra, ACT 2601, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Robin","sequence":"additional","affiliation":[{"name":"1 The Bio21 Institute"},{"name":"2 School of Biosciences, The University of Melbourne, Melbourne 3010, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,12,24]]},"reference":[{"key":"2023020112210663200_btv747-B1","doi-asserted-by":"crossref","first-page":"W582","DOI":"10.1093\/nar\/gki468","article-title":"E-RNAi: a web application to design optimized RNAi constructs","volume":"33","author":"Arziman","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"2023020112210663200_btv747-B2","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s11248-013-9716-5","article-title":"Characterization of the spectrum of insecticidal activity of a double-stranded RNA with targeted activity against Western Corn Rootworm (Diabrotica virgifera virgifera LeConte)","volume":"22","author":"Bachman","year":"2013","journal-title":"Transgenic Res"},{"key":"2023020112210663200_btv747-B3","doi-asserted-by":"crossref","first-page":"e47534","DOI":"10.1371\/journal.pone.0047534","article-title":"Characterizing the mechanism of action of double-stranded RNA activity against western corn rootworm (Diabrotica virgifera virgifera LeConte)","volume":"7","author":"Bolognesi","year":"2012","journal-title":"PLoS ONE"},{"key":"2023020112210663200_btv747-B4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cois.2014.09.012","article-title":"The challenge of RNAi-mediated control of hemipterans","volume":"6","author":"Christiaens","year":"2014","journal-title":"Curr. 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