{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:17:11Z","timestamp":1772551031018,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":229,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Immunoinformatics approaches are widely used in a variety of applications from basic immunological to applied biomedical research. Complex data integration is inevitable in immunological research and usually requires comprehensive pipelines including multiple tools and data sources. Non-standard input and output formats of immunoinformatics tools make the development of such applications difficult. Here we present FRED 2, an open-source immunoinformatics framework offering easy and unified access to methods for epitope prediction and other immunoinformatics applications. FRED 2 is implemented in Python and designed to be extendable and flexible to allow rapid prototyping of complex applications.<\/jats:p>\n               <jats:p>Availability and implementation: FRED 2 is available at http:\/\/fred-2.github.io<\/jats:p>\n               <jats:p>Contact: \u00a0schubert@informatik.uni-tuebingen.de<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btw113","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T02:10:41Z","timestamp":1456539041000},"page":"2044-2046","source":"Crossref","is-referenced-by-count":38,"title":["FRED 2: an immunoinformatics framework for Python"],"prefix":"10.1093","volume":"32","author":[{"given":"Benjamin","family":"Schubert","sequence":"first","affiliation":[{"name":"1 Center for Bioinformatics, University of T\u00fcbingen, T\u00fcbingen 72076, Germany"},{"name":"2 Department of Computer Science, Applied Bioinformatics, T\u00fcbingen 72076, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Walzer","sequence":"additional","affiliation":[{"name":"1 Center for Bioinformatics, University of T\u00fcbingen, T\u00fcbingen 72076, Germany"},{"name":"2 Department of Computer Science, Applied Bioinformatics, T\u00fcbingen 72076, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Philipp","family":"Brachvogel","sequence":"additional","affiliation":[{"name":"1 Center for Bioinformatics, University of T\u00fcbingen, T\u00fcbingen 72076, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e1s","family":"Szolek","sequence":"additional","affiliation":[{"name":"1 Center for Bioinformatics, University of T\u00fcbingen, T\u00fcbingen 72076, Germany"},{"name":"2 Department of Computer Science, Applied Bioinformatics, T\u00fcbingen 72076, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Mohr","sequence":"additional","affiliation":[{"name":"1 Center for Bioinformatics, University of T\u00fcbingen, T\u00fcbingen 72076, Germany"},{"name":"2 Department of Computer Science, Applied Bioinformatics, T\u00fcbingen 72076, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Kohlbacher","sequence":"additional","affiliation":[{"name":"1 Center for Bioinformatics, University of T\u00fcbingen, T\u00fcbingen 72076, Germany"},{"name":"2 Department of Computer Science, Applied Bioinformatics, T\u00fcbingen 72076, Germany"},{"name":"3 Quantitative Biology Center, T\u00fcbingen 72076, Germany"},{"name":"4 Faculty of Medicine, University of T\u00fcbingen, T\u00fcbingen 72076, Germany"},{"name":"5 Max Planck Institute for Developmental Biology, Biomolecular Interactions, T\u00fcbingen 72076, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,2,26]]},"reference":[{"key":"2023020112340814600_btw113-B1","doi-asserted-by":"crossref","first-page":"407.","DOI":"10.1186\/1756-0500-6-407","article-title":"PolyCTLDesigner: a computational tool for constructing polyepitope T-cell antigens","volume":"6","author":"Antonets","year":"2013","journal-title":"BMC Res. 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