{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:32:06Z","timestamp":1773275526471,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Summary: Hilbert curves enable high-resolution visualization of genomic data on a chromosome- or genome-wide scale. Here we present the HilbertCurve package that provides an easy-to-use interface for mapping genomic data to Hilbert curves. The package transforms the curve as a virtual axis, thereby hiding the details of the curve construction from the user. HilbertCurve supports multiple-layer overlay that makes it a powerful tool to correlate the spatial distribution of multiple feature types.<\/jats:p>\n               <jats:p>Availability and implementation: The HilbertCurve package and documentation are freely available from the Bioconductor project: http:\/\/www.bioconductor.org\/packages\/devel\/bioc\/html\/HilbertCurve.html<\/jats:p>\n               <jats:p>Contact: \u00a0m.schlesner@dkfz.de<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btw161","type":"journal-article","created":{"date-parts":[[2016,3,26]],"date-time":"2016-03-26T00:23:39Z","timestamp":1458951819000},"page":"2372-2374","source":"Crossref","is-referenced-by-count":31,"title":["HilbertCurve: an R\/Bioconductor package for high-resolution visualization of genomic data"],"prefix":"10.1093","volume":"32","author":[{"given":"Zuguang","family":"Gu","sequence":"first","affiliation":[{"name":"1 Division of Theoretical Bioinformatics"},{"name":"2 Heidelberg Center for Personalized Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany"}]},{"given":"Roland","family":"Eils","sequence":"additional","affiliation":[{"name":"1 Division of Theoretical Bioinformatics"},{"name":"2 Heidelberg Center for Personalized Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany"},{"name":"3 Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany"}]},{"given":"Matthias","family":"Schlesner","sequence":"additional","affiliation":[{"name":"1 Division of Theoretical Bioinformatics"}]}],"member":"286","published-online":{"date-parts":[[2016,3,24]]},"reference":[{"key":"2023020112483057100_btw161-B1","doi-asserted-by":"crossref","first-page":"10.","DOI":"10.1093\/bioinformatics\/btp152","article-title":"Visualization of genomic data with Hilbert Curve","volume":"25","author":"Anders","year":"2009","journal-title":"Bioinformatics"},{"key":"2023020112483057100_btw161-B2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/nar\/gks671","article-title":"Cell type-specific genomics of Drosophila neurons","volume":"40","author":"Henry","year":"2012","journal-title":"Nucleic Acid Res"},{"key":"2023020112483057100_btw161-B3","doi-asserted-by":"crossref","first-page":"459.","DOI":"10.1007\/BF01199431","article-title":"\u00dcber stetige Abbildungen einer Linie auf ein Fl\u00e4chenst\u00fcck","volume":"38","author":"Hilbert","year":"1891","journal-title":"Math. 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