{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T04:25:47Z","timestamp":1775190347583,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"18","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"vor","delay-in-days":170,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Motivation: Many drug combinations are routinely assessed to identify synergistic interactions in the attempt to develop novel treatment strategies. Appropriate software is required to analyze the results of these studies.<\/jats:p><jats:p>Results: We present Combenefit, new free software tool that enables the visualization, analysis and quantification of drug combination effects in terms of synergy and\/or antagonism. Data from combinations assays can be processed using classical Synergy models (Loewe, Bliss, HSA), as single experiments or in batch for High Throughput Screens. This user-friendly tool provides laboratory scientists with an easy and systematic way to analyze their data. The companion package provides bioinformaticians with critical implementations of routines enabling the processing of combination data.<\/jats:p><jats:p>Availability and Implementation: Combenefit is provided as a Matlab package but also as standalone software for Windows (http:\/\/sourceforge.net\/projects\/combenefit\/).<\/jats:p><jats:p>Contact: \u00a0Giovanni.DiVeroli@cruk.cam.ac.uk<\/jats:p><jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btw230","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T00:43:07Z","timestamp":1461717787000},"page":"2866-2868","source":"Crossref","is-referenced-by-count":674,"title":["Combenefit: an interactive platform for the analysis and visualization of drug combinations"],"prefix":"10.1093","volume":"32","author":[{"given":"Giovanni Y.","family":"Di Veroli","sequence":"first","affiliation":[{"name":"1 CRUK Cambridge Institute, University of Cambridge, Cambridge, UK"},{"name":"2 Early Clinical Development, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Cambridge, UK"}]},{"given":"Chiara","family":"Fornari","sequence":"additional","affiliation":[{"name":"1 CRUK Cambridge Institute, University of Cambridge, Cambridge, UK"}]},{"given":"Dennis","family":"Wang","sequence":"additional","affiliation":[{"name":"3 Bioinformatics, Oncology Innovative Medicines, AstraZeneca, Cambridge, UK"}]},{"given":"S\u00e9verine","family":"Mollard","sequence":"additional","affiliation":[{"name":"1 CRUK Cambridge Institute, University of Cambridge, Cambridge, UK"}]},{"given":"Jo L.","family":"Bramhall","sequence":"additional","affiliation":[{"name":"1 CRUK Cambridge Institute, University of Cambridge, Cambridge, UK"}]},{"given":"Frances M.","family":"Richards","sequence":"additional","affiliation":[{"name":"1 CRUK Cambridge Institute, University of Cambridge, Cambridge, UK"}]},{"given":"Duncan I.","family":"Jodrell","sequence":"additional","affiliation":[{"name":"1 CRUK Cambridge Institute, University of Cambridge, Cambridge, UK"}]}],"member":"286","published-online":{"date-parts":[[2016,4,25]]},"reference":[{"key":"2023020113392312900_btw230-B1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1744-7348.1939.tb06990.x","article-title":"The toxicity of poisons applied jointly","volume":"26","author":"Bliss","year":"1939","journal-title":"Ann. Appl. Biol"},{"key":"2023020113392312900_btw230-B2","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou\u2013Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res"},{"key":"2023020113392312900_btw230-B3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/cbmr.1999.1509","article-title":"CombiTool\u2013a new computer program for analyzing combination experiments with biologically active agents","volume":"32","author":"Dressler","year":"1999","journal-title":"Comput. Biomed. Res"},{"key":"2023020113392312900_btw230-B4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0031-6997(25)06847-4","article-title":"The search for synergy: a critical review from a response surface perspective","volume":"47","author":"Greco","year":"1995","journal-title":"Pharmacol. Rev"},{"key":"2023020113392312900_btw230-B5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.3010286","article-title":"Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection","volume":"7","author":"He","year":"2015","journal-title":"Sci. Transl. Med"},{"key":"2023020113392312900_btw230-B6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1158\/2159-8290.CD-12-0408","article-title":"Genotype-selective combination therapies for melanoma identified by high-throughput drug screening","volume":"3","author":"Held","year":"2013","journal-title":"Cancer Discov"},{"key":"2023020113392312900_btw230-B7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nbt.1549","article-title":"Synergistic drug combinations tend to improve therapeutically relevant selectivity","volume":"27","author":"Leh\u00e1r","year":"2009","journal-title":"Nat. Biotechnol"},{"key":"2023020113392312900_btw230-B8","first-page":"286","article-title":"The problem of synergism and antagonism of combined drugs","volume":"3","author":"Loewe","year":"1953","journal-title":"ArzneimiettelForschung"},{"key":"2023020113392312900_btw230-B9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF01952257","article-title":"Effect of combinations: mathematical basis of problem","volume":"114","author":"Loewe","year":"1926","journal-title":"Arch. Exp. Pathol. Pharmacol"},{"key":"2023020113392312900_btw230-B10","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1038\/ncomms6694","article-title":"Increased MAPK reactivation in early resistance to dabrafenib\/trametinib combination therapy of BRAF-mutant metastatic melanoma","volume":"5","author":"Long","year":"2014","journal-title":"Nat. Commun"},{"key":"2023020113392312900_btw230-B11","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1073\/pnas.1311846111","article-title":"High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells","volume":"111","author":"Mathews Griner","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023020113392312900_btw230-B12","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1093\/jac\/dkg301","article-title":"Synergy, antagonism, and what the chequerboard puts between them","volume":"52","author":"Odds","year":"2003","journal-title":"J. Antimicrob. Chemother"},{"key":"2023020113392312900_btw230-B13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0166-3542(90)90001-N","article-title":"A three-dimensional model to analyze drug-drug interactions","volume":"14","author":"Prichard","year":"1990","journal-title":"Antiviral Res"},{"key":"2023020113392312900_btw230-B14","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nchembio.1205","article-title":"Systems-level antimicrobial drug and drug synergy discovery","volume":"9","author":"Roemer","year":"2013","journal-title":"Nat. Chem. Biol"},{"key":"2023020113392312900_btw230-B15","doi-asserted-by":"crossref","first-page":"205rv1","DOI":"10.1126\/scitranslmed.3006667","article-title":"High-throughput methods for combinatorial drug discovery","volume":"5","author":"Sun","year":"2013","journal-title":"Sci. Trans. Med"},{"key":"2023020113392312900_btw230-B16","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nbt.2391","article-title":"Systematic identification of synergistic drug pairs targeting HIV","volume":"30","author":"Tan","year":"2012","journal-title":"Nat. Biotechnol"},{"key":"2023020113392312900_btw230-B17","first-page":"66","article-title":"Effect of more than one inhibitor","volume":"1","author":"Webb","year":"1963","journal-title":"Enzyme Metab. Inhib"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/32\/18\/2866\/49021000\/bioinformatics_32_18_2866.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/32\/18\/2866\/49021000\/bioinformatics_32_18_2866.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T22:01:06Z","timestamp":1748901666000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/32\/18\/2866\/1743073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,25]]},"references-count":17,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2016,9,15]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btw230","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,9,15]]},"published":{"date-parts":[[2016,4,25]]}}}