{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:54:40Z","timestamp":1767963280547,"version":"3.49.0"},"reference-count":6,"publisher":"Oxford University Press (OUP)","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Transient S-sulfenylation of cysteine thiols mediated by reactive oxygen species plays a critical role in pathology, physiology and cell signaling. Therefore, discovery of new S-sulfenylated sites in proteins is of great importance towards understanding how protein function is regulated upon redox conditions.<\/jats:p>\n               <jats:p>Results: We developed PRESS (PRotEin S-Sulfenylation) web server, a server which can effectively predict the cysteine thiols of a protein that could undergo S-sulfenylation under redox conditions. We envisage that this server will boost and facilitate the discovery of new and currently unknown functions of proteins triggered upon redox conditions, signal regulation and transduction, thus uncovering the role of S-sulfenylation in human health and disease.<\/jats:p>\n               <jats:p>Availability and implementation: The PRESS web server is freely available at http:\/\/press-sulfenylation.cse.uoi.gr\/<\/jats:p>\n               <jats:p>Contacts: \u00a0agtzakos@gmail.com or gtzortzi@cs.uoi.gr<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btw301","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T02:25:40Z","timestamp":1463192740000},"page":"2710-2712","source":"Crossref","is-referenced-by-count":16,"title":["PRESS: PRotEin S-Sulfenylation server"],"prefix":"10.1093","volume":"32","author":[{"given":"Marianna","family":"Sakka","sequence":"first","affiliation":[{"name":"1 Department of Chemistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigorios","family":"Tzortzis","sequence":"additional","affiliation":[{"name":"2 Department of Computer Science and Engineering"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michalis D.","family":"Mantzaris","sequence":"additional","affiliation":[{"name":"3 Laboratory of Biological Chemistry Faculty of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Bekas","sequence":"additional","affiliation":[{"name":"1 Department of Chemistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahsin F.","family":"Kellici","sequence":"additional","affiliation":[{"name":"1 Department of Chemistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aristidis","family":"Likas","sequence":"additional","affiliation":[{"name":"2 Department of Computer Science and Engineering"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Galaris","sequence":"additional","affiliation":[{"name":"3 Laboratory of Biological Chemistry Faculty of Medicine, University of Ioannina, Ioannina, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis P.","family":"Gerothanassis","sequence":"additional","affiliation":[{"name":"1 Department of Chemistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas G.","family":"Tzakos","sequence":"additional","affiliation":[{"name":"1 Department of Chemistry"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,5,13]]},"reference":[{"key":"2023020112593465000_btw301-B1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"2023020112593465000_btw301-B2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.chembiol.2015.04.013","article-title":"Peroxide-dependent MGL sulfenylation regulates 2-AG-mediated endocannabinoid signaling in brain neurons","volume":"22","author":"Dotsey","year":"2015","journal-title":"Chem. 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