{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T21:24:50Z","timestamp":1771622690355,"version":"3.50.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T00:00:00Z","timestamp":1478736000000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Motivation: For genetic studies, statistically significant variants explain far less trait variance than \u2018sub-threshold\u2019 association signals. To dimension follow-up studies, researchers need to accurately estimate \u2018true\u2019 effect sizes at each SNP, e.g. the true mean of odds ratios (ORs)\/regression coefficients (RRs) or Z -score noncentralities. Na\u00efve estimates of effect sizes incur winner\u2019s curse biases, which are reduced only by laborious winner\u2019s curse adjustments (WCAs). Given that Z -scores estimates can be theoretically translated on other scales, we propose a simple method to compute WCA for Z -scores, i.e. their true means\/noncentralities.<\/jats:p><jats:p>Results: WCA of Z -scores shrinks these towards zero while, on P -value scale, multiple testing adjustment (MTA) shrinks P -values toward one, which corresponds to the zero Z -score value. Thus, WCA on Z -scores scale is a proxy for MTA on P -value scale. Therefore, to estimate Z -score noncentralities for all SNPs in genome scans, we propose F DR I nverse Q uantile T ransformation (FIQT). It (i) performs the simpler MTA of P -values using FDR and (ii) obtains noncentralities by back-transforming MTA P -values on Z -score scale. When compared to competitors, realistic simulations suggest that FIQT is more (i) accurate and (ii) computationally efficient by orders of magnitude. Practical application of FIQT to Psychiatric Genetic Consortium schizophrenia cohort predicts a non-trivial fraction of sub-threshold signals which become significant in much larger supersamples.<\/jats:p><jats:p>Conclusions : FIQT is a simple, yet accurate, WCA method for Z -scores (and ORs\/RRs, via simple transformations).<\/jats:p><jats:p>Availability and Implementation: A 10 lines R function implementation is available at https:\/\/github.com\/bacanusa\/FIQT .<\/jats:p><jats:p>Contact: \u00a0sabacanu@vcu.edu<\/jats:p><jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btw303","type":"journal-article","created":{"date-parts":[[2016,5,14]],"date-time":"2016-05-14T02:25:40Z","timestamp":1463192740000},"page":"2598-2603","source":"Crossref","is-referenced-by-count":51,"title":["A simple yet accurate correction for winner's curse can predict signals discovered in much larger genome scans"],"prefix":"10.1093","volume":"32","author":[{"given":"T. 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