{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T10:11:19Z","timestamp":1675332679009},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Two-component systems (TCS) are the main signalling pathways of prokaryotes, and control a wide range of biological phenomena. Their functioning depends on interactions between TCS proteins, the specificity of which is poorly understood.<\/jats:p>\n               <jats:p>Results: The MetaPred2CS web-server interfaces a sequence-based meta-predictor specifically designed to predict pairing of the histidine kinase and response-regulator proteins forming TCSs. MetaPred2CS integrates six sequence-based methods using a support vector machine classifier and has been intensively tested under different benchmarking conditions: (i) species specific gene sets; (ii) neighbouring versus orphan pairs; and (iii) k-fold cross validation on experimentally validated datasets.<\/jats:p>\n               <jats:p>Availability and Implementation: Web server at: http:\/\/metapred2cs.ibers.aber.ac.uk\/ , Source code: https:\/\/github.com\/martinjvickers\/MetaPred2CS or implemented as Virtual Machine at: http:\/\/metapred2cs.ibers.aber.ac.uk\/download<\/jats:p>\n               <jats:p>Contact: \u00a0naf4@aber.ac.uk<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btw403","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T01:59:34Z","timestamp":1467683974000},"page":"3339-3341","source":"Crossref","is-referenced-by-count":1,"title":["MetaPred2CS: a sequence-based meta-predictor for protein\u2013protein interactions of prokaryotic two-component system proteins"],"prefix":"10.1093","volume":"32","author":[{"given":"Altan","family":"Kara","sequence":"first","affiliation":[{"name":"Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth SY23 3EB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Vickers","sequence":"additional","affiliation":[{"name":"Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth SY23 3EB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Swain","sequence":"additional","affiliation":[{"name":"Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth SY23 3EB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Whitworth","sequence":"additional","affiliation":[{"name":"Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth SY23 3EB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narcis","family":"Fernandez-Fuentes","sequence":"additional","affiliation":[{"name":"Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth SY23 3EB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,7,4]]},"reference":[{"key":"2023020113514042700_btw403-B1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1128\/JB.186.4.1001-1008.2004","article-title":"Myxococcus xanthus chemotaxis\n               homologs DifD and DifG negatively regulate fibril polysaccharide production","volume":"186","author":"Black","year":"2004","journal-title":"J. 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