{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:06:59Z","timestamp":1782227219039,"version":"3.54.5"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Summary: Detecting periodicity in large scale data remains a challenge. While efforts have been made to identify best of breed algorithms, relatively little research has gone into integrating these methods in a generalizable method. Here, we present MetaCycle, an R package that incorporates ARSER, JTK_CYCLE and Lomb-Scargle to conveniently evaluate periodicity in time-series data. MetaCycle has two functions, meta2d and meta3d, designed to analyze two-dimensional and three-dimensional time-series datasets, respectively. Meta2d implements N-version programming concepts using a suite of algorithms and integrating their results.<\/jats:p>\n                  <jats:p>Availability and implementation: MetaCycle package is available on the CRAN repository ( https:\/\/cran.r-project.org\/web\/packages\/MetaCycle\/index.html ) and GitHub ( https:\/\/github.com\/gangwug\/MetaCycle ).<\/jats:p>\n                  <jats:p>Contact: \u00a0hogenesch@gmail.com<\/jats:p>\n                  <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btw405","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T21:59:34Z","timestamp":1467669574000},"page":"3351-3353","source":"Crossref","is-referenced-by-count":569,"title":["MetaCycle: an integrated R package to evaluate periodicity in large scale data"],"prefix":"10.1093","volume":"32","author":[{"given":"Gang","family":"Wu","sequence":"first","affiliation":[{"name":"1 Department of Systems Pharmacology and Translational Therapeutics, Institute for Translational Medicine and Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron C.","family":"Anafi","sequence":"additional","affiliation":[{"name":"2 Division of Sleep Medicine"},{"name":"3 Center for Sleep and Circadian Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Hughes","sequence":"additional","affiliation":[{"name":"4 Department of Biology, University of Missouri\u2013St. Louis, St. Louis, MO 63121, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Kornacker","sequence":"additional","affiliation":[{"name":"5 Emeritus Professor of Sensory Biophysics, the Ohio State University, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Hogenesch","sequence":"additional","affiliation":[{"name":"1 Department of Systems Pharmacology and Translational Therapeutics, Institute for Translational Medicine and Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,7,4]]},"reference":[{"key":"2023020113514028700_btw405-B1","first-page":"149","author":"Avizienis","year":"1977"},{"key":"2023020113514028700_btw405-B2","first-page":"23","volume-title":"The Methodology of N-Version Programming, Software Fault Tolerance","author":"Avizienis","year":"1995"},{"key":"2023020113514028700_btw405-B3","first-page":"3","author":"Chen","year":"1978"},{"key":"2023020113514028700_btw405-B5","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1093\/bioinformatics\/btt541","article-title":"Design and analysis of large-scale biological rhythm studies: a comparison of algorithms for detecting periodic signals in biological data","volume":"29","author":"Deckard","year":"2013","journal-title":"Bioinformatics"},{"key":"2023020113514028700_btw405-B6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev-genet-102209-163432","article-title":"Circadian control of global gene expression patterns","volume":"44","author":"Doherty","year":"2010","journal-title":"Annu. 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