{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:45:37Z","timestamp":1740185137302,"version":"3.37.3"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:00:00Z","timestamp":1468368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009023","name":"Precursory Research for Embryonic Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009023","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"crossref","award":["14469361","15H05711","15H01717","15H05713","24240044"],"award-info":[{"award-number":["14469361","15H05711","15H01717","15H05713","24240044"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11,15]]},"abstract":"<jats:p>Summary: One of the major issues in genome-wide association studies is to solve the missing heritability problem. While considering epistatic interactions among multiple SNPs may contribute to solving this problem, existing software cannot detect statistically significant high-order interactions. We propose software named LAMPLINK, which employs a cutting-edge method to enumerate statistically significant SNP combinations from genome-wide case\u2013control data. LAMPLINK is implemented as a set of additional functions to PLINK, and hence existing procedures with PLINK can be applicable. Applied to the 1000 Genomes Project data, LAMPLINK detected a combination of five SNPs that are statistically significantly accumulated in the Japanese population.<\/jats:p>\n               <jats:p>Availability and Implementation: LAMPLINK is available at http:\/\/a-terada.github.io\/lamplink\/.<\/jats:p>\n               <jats:p>Contact: \u00a0terada@cbms.k.u-tokyo.ac.jp or sese.jun@aist.go.jp<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btw418","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T06:18:47Z","timestamp":1468477127000},"page":"3513-3515","source":"Crossref","is-referenced-by-count":19,"title":["LAMPLINK: detection of statistically significant SNP combinations from GWAS data"],"prefix":"10.1093","volume":"32","author":[{"given":"Aika","family":"Terada","sequence":"first","affiliation":[{"name":"1PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan"},{"name":"2Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8561, Japan"},{"name":"3Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan"}]},{"given":"Ryo","family":"Yamada","sequence":"additional","affiliation":[{"name":"4Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507 Japan"}]},{"given":"Koji","family":"Tsuda","sequence":"additional","affiliation":[{"name":"2Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8561, Japan"},{"name":"3Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan"},{"name":"5Center for Materials Research by Information Integration, NIMS, Ibaraki, 305-0047 Japan"}]},{"given":"Jun","family":"Sese","sequence":"additional","affiliation":[{"name":"3Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan"},{"name":"6Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan"}]}],"member":"286","published-online":{"date-parts":[[2016,7,13]]},"reference":[{"key":"2023020114063984300_btw418-B1","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1093\/bioinformatics\/btq352","article-title":"mbmdr: an R package for exploring gene-gene interactions associated with binary or quantitative traits","volume":"26","author":"Calle","year":"2010","journal-title":"Bioinformatics"},{"key":"2023020114063984300_btw418-B2","first-page":"519","article-title":"A simple method for testing two-locus models of inheritance","volume":"33","author":"Greenberg","year":"1981","journal-title":"Am. 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