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Its capabilities render DEsubs a tool-guide for both the modeler and experimentalist for the identification of more robust systems-level drug targets and biomarkers for complex diseases.<\/jats:p>\n               <jats:p>Availability and Implementation: DEsubs is implemented as an R package following Bioconductor guidelines: http:\/\/bioconductor.org\/packages\/DEsubs\/.<\/jats:p>\n               <jats:p>Contact: \u00a0tassos.bezerianos@nus.edu.sg<\/jats:p>\n               <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btw544","type":"journal-article","created":{"date-parts":[[2016,8,20]],"date-time":"2016-08-20T01:49:34Z","timestamp":1471657774000},"page":"3844-3846","source":"Crossref","is-referenced-by-count":31,"title":["DEsubs: an R package for flexible identification of differentially expressed subpathways using RNA-seq experiments"],"prefix":"10.1093","volume":"32","author":[{"given":"Aristidis G.","family":"Vrahatis","sequence":"first","affiliation":[{"name":"1Department of Computer Engineering and Informatics"},{"name":"2Department of Medicine, University of Patras, Patras, 26500, GR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panos","family":"Balomenos","sequence":"additional","affiliation":[{"name":"1Department of Computer Engineering and Informatics"},{"name":"2Department of Medicine, University of Patras, Patras, 26500, GR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios K.","family":"Tsakalidis","sequence":"additional","affiliation":[{"name":"1Department of Computer Engineering and Informatics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasios","family":"Bezerianos","sequence":"additional","affiliation":[{"name":"2Department of Medicine, University of Patras, Patras, 26500, GR"},{"name":"3SINAPSE Institute, Center of Life Sciences, National University of Singapore, Singapore 117456"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,8,19]]},"reference":[{"key":"2023020114111210900_btw544-B1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrg2918","article-title":"Network medicine: a network-based approach to human disease","volume":"12","author":"Barab\u00e1si","year":"2011","journal-title":"Nat. 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