{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T20:35:42Z","timestamp":1775334942854,"version":"3.50.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"24","funder":[{"name":"NIH","award":["R01GM078204"],"award-info":[{"award-number":["R01GM078204"]}]},{"name":"National Institutes of Health under Ruth L. Kirschstein National Research Service","award":["F32 GM105231"],"award-info":[{"award-number":["F32 GM105231"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,15]]},"abstract":"<jats:p>Summary: Here we describe discoal, a coalescent simulator able to generate population samples that include selective sweeps in a feature-rich, flexible manner. discoal can perform simulations conditioning on the fixation of an allele due to drift or either hard or soft sweeps\u2014even those occurring a large genetic distance away from the simulated locus. discoal can simulate sweeps with recurrent mutation to the adaptive allele, recombination, and gene conversion, under non-equilibrium demographic histories and without specifying an allele frequency trajectory in advance.<\/jats:p>\n                  <jats:p>Availability and Implementation: discoal is implemented in the C programming language. Source code is freely available on GitHub (https:\/\/github.com\/kern-lab\/discoal) under a GNU General Public License.<\/jats:p>\n                  <jats:p>Contact: \u00a0kern@dls.rutgers.edu or dan.schrider@rutgers.edu<\/jats:p>\n                  <jats:p>Supplementary information: \u00a0Supplementary data are available at Bioinformatics online.<\/jats:p>","DOI":"10.1093\/bioinformatics\/btw556","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T22:49:07Z","timestamp":1472078947000},"page":"3839-3841","source":"Crossref","is-referenced-by-count":106,"title":["Discoal: flexible coalescent simulations with selection"],"prefix":"10.1093","volume":"32","author":[{"given":"Andrew D.","family":"Kern","sequence":"first","affiliation":[{"name":"1Department of Genetics"},{"name":"2Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08554, USA"}]},{"given":"Daniel R.","family":"Schrider","sequence":"additional","affiliation":[{"name":"2Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08554, USA"}]}],"member":"286","published-online":{"date-parts":[[2016,8,24]]},"reference":[{"key":"2023020114102324100_btw556-B1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/genetics\/140.2.783","article-title":"The hitchhiking effect on the site frequency spectrum of DNA polymorphisms","volume":"140","author":"Braverman","year":"1995","journal-title":"Genetics"},{"key":"2023020114102324100_btw556-B2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tpb.2004.06.006","article-title":"Ancestral inference on gene trees under selection","volume":"66","author":"Coop","year":"2004","journal-title":"Theor. 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