{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:56:33Z","timestamp":1783479393959,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Ancestry and Kinship Toolkit (AKT) is a statistical genetics tool for analysing large cohorts of whole-genome sequenced samples. It can rapidly detect related samples, characterize sample ancestry, calculate correlation between variants, check Mendel consistency and perform data clustering. AKT brings together the functionality of many state-of-the-art methods, with a focus on speed and a unified interface. We believe it will be an invaluable tool for the curation of large WGS datasets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and Implementation<\/jats:title>\n                    <jats:p>The source code is available at https:\/\/illumina.github.io\/akt.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Supplementary information<\/jats:title>\n                    <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw576","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T20:10:35Z","timestamp":1473970235000},"page":"142-144","source":"Crossref","is-referenced-by-count":46,"title":["AKT: ancestry and kinship toolkit"],"prefix":"10.1093","volume":"33","author":[{"given":"Rudy","family":"Arthur","sequence":"first","affiliation":[{"name":"Illumina Cambridge Ltd., Chesterford Research Park, Little Chesterford, Essex, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Schulz-Trieglaff","sequence":"additional","affiliation":[{"name":"Illumina Cambridge Ltd., Chesterford Research Park, Little Chesterford, Essex, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J","family":"Cox","sequence":"additional","affiliation":[{"name":"Illumina Cambridge Ltd., Chesterford Research Park, Little Chesterford, Essex, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Illumina Cambridge Ltd., Chesterford Research Park, Little Chesterford, Essex, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,9,14]]},"reference":[{"key":"2023020204202077300_btw576-B1","first-page":"291","article-title":"LD score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nature"},{"key":"2023020204202077300_btw576-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13742-015-0047-8","article-title":"Second-generation plink: rising to the challenge of larger and richer datasets","volume":"4","author":"Chang","year":"2015","journal-title":"Gigascience"},{"key":"2023020204202077300_btw576-B3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/ng.3247","article-title":"Large-scale whole-genome sequencing of the Icelandic population","volume":"47","author":"Gudbjartsson","year":"2015","journal-title":"Nat. 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