{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T06:48:04Z","timestamp":1759042084470},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"National Natural Scientific Fund of China","award":["81472925"],"award-info":[{"award-number":["81472925"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Motivation<\/jats:title>\n                  <jats:p>Pathway association analysis has made great achievements in elucidating the genetic basis of human complex diseases. However, current pathway association analysis approaches fail to consider tissue-specificity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We developed a tissue-specific pathway interaction enrichment analysis algorithm (TPIEA). TPIEA was applied to two large Caucasian and Chinese genome-wide association study summary datasets of bone mineral density (BMD). TPIEA identified several significant pathways for BMD [false discovery rate (FDR)\u2009&amp;lt;\u20090.05], such as KEGG FOCAL ADHESION and KEGG AXON GUIDANCE, which had been demonstrated to be involved in the development of osteoporosis. We also compared the performance of TPIEA and classical pathway enrichment analysis, and TPIEA presented improved performance in recognizing disease relevant pathways. TPIEA may help to fill the gap of classic pathway association analysis approaches by considering tissue specificity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Availability and Implementation<\/jats:title>\n                  <jats:p>The online web tool of TPIEA is available at https:\/\/sourceforge.net\/projects\/tpieav1\/files.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Supplementary information<\/jats:title>\n                  <jats:p>Supplementary data are available at Bioinformatics online.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btw595","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T03:08:44Z","timestamp":1474427324000},"page":"243-247","source":"Crossref","is-referenced-by-count":9,"title":["Tissue-specific pathway association analysis using genome-wide association study summaries"],"prefix":"10.1093","volume":"33","author":[{"given":"Wenyu","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingcan","family":"Hao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, First Affiliated Hospital, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianrui","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awen","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Trace Elements and Endemic Diseases of National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi\u2019an Jiaotong University, Xi\u2019an, P.R. 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA"},{"name":"Center for Bioinformatics and Genomics, Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangding","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Tulane University School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA"},{"name":"Center for Bioinformatics and Genomics, Tulane University, New Orleans, LA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Tan","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, P. R. 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